{"id":68288,"date":"2023-01-05T15:04:04","date_gmt":"2023-01-05T20:04:04","guid":{"rendered":"https:\/\/blog.jackjia.com\/?p=68288"},"modified":"2023-01-05T15:04:04","modified_gmt":"2023-01-05T20:04:04","slug":"20230105-%e6%9c%80%e6%96%b0%e7%a0%94%e7%a9%b6%ef%bc%9acovid-19%e4%ba%a1%e8%80%85%e5%b0%b8%e6%a3%80%e5%8f%91%e7%8e%b0%e7%97%85%e6%af%92%e4%b8%8d%e9%99%90%e4%ba%8e%e5%91%bc%e5%90%b8%e7%b3%bb%e7%bb%9f","status":"publish","type":"post","link":"https:\/\/blog.jackjia.com\/?p=68288","title":{"rendered":"20230105\/\u6700\u65b0\u7814\u7a76\uff1aCOVID-19\u4ea1\u8005\u5c38\u68c0\u53d1\u73b0\u75c5\u6bd2\u4e0d\u9650\u4e8e\u547c\u5438\u7cfb\u7edf\uff0c\u8fd8\u51fa\u73b0\u5728\u5927\u8111\u548c\u591a\u4e2a\u5668\u5b98\u4e2d\u2026\u2026"},"content":{"rendered":"

\uff08\u661f\u661f\u751f\u6d3b\/\u6377\u514b\u4f73\uff092022\u5e7412\u6708\u53d1\u8868\u5728\u540c\u884c\u8bc4\u5ba1\u671f\u520a\u300a\u81ea\u7136\u300b\uff08(Nature)\u4e0a\u5bf9\u5c38\u68c0\u7ed3\u679c\u7684\u63cf\u8ff0\uff0c\u7a81\u51fa\u4e86\u611f\u67d3\u8d1f\u62c5\u7684\u6df1\u8fdc\u5f71\u54cd\uff0c\u572844\u540d\u60a3\u8005\u4f53\u518585\u4e2a\u90e8\u4f4d\u4e2d\u768479\u4e2a\u53d1\u73b0\u4e86\u75c5\u6bd2\u7247\u6bb5\u3002<\/p>\n

\"\"<\/a><\/p>\n

44\u540dCOVID-19\u4ea1\u8005\u7684\u5c38\u68c0\u7ed3\u679c\u8868\u660e\uff0c\u75c5\u6bd2\u4e0d\u4ec5\u901a\u8fc7\u547c\u5438\u7cfb\u7edf\u4f20\u64ad\uff0c\u800c\u4e14\u8fd8\u901a\u8fc7\u6574\u4e2a\u8eab\u4f53\uff08\u5305\u62ec\u5927\u8111\uff09\u5728\u4e00\u4e9b\u60a3\u8005\u8eab\u4e0a\u6301\u7eed\u4f20\u64ad\u6570\u6708\u3002<\/p>\n

\u636e\u5176\u4f5c\u8005\u79f0\uff0c\u8fd9\u9879\u5c0f\u578b\u7814\u7a76\u5f62\u6210\u4e86\u201c\u8fc4\u4eca\u4e3a\u6b62\u5bf9SARS-CoV-2\u5728\u4eba\u4f53\uff08\u5305\u62ec\u5927\u8111\uff09\u4e2d\u7684\u7ec6\u80de\u8d8b\u5411\u6027\u3001\u91cf\u5316\u548c\u6301\u4e45\u6027\u7684\u6700\u5168\u9762\u5206\u6790\u201d\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4f5c\u8005\u5728\u8bba\u6587\u6458\u8981\u4e2d\u5199\u9053\uff1a<\/p>\n

\u5df2\u77e5\u51a0\u72b6\u75c5\u6bd2\u75c52019 (COVID-19) \u5728\u4e25\u91cd\u6025\u6027\u547c\u5438\u7cfb\u7edf\u7efc\u5408\u75c7\u51a0\u72b6\u75c5\u6bd22 (SARS-CoV-2) \u6025\u6027\u611f\u67d3\u671f\u95f4\u4f1a\u5bfc\u81f4\u591a\u5668\u5b98\u529f\u80fd\u969c\u788d\uff0c\u4e00\u4e9b\u60a3\u8005\u51fa\u73b0\u957f\u671f\u75c7\u72b6\uff0c\u79f0\u4e3aSARS-CoV-2\u6025\u6027\u540e\u9057\u75c7\u3002\u7136\u800c\uff0c\u547c\u5438\u9053\u5916\u7684\u611f\u67d3\u8d1f\u62c5\u548c\u75c5\u6bd2\u6e05\u9664\u65f6\u95f4\u5c1a\u672a\u5f97\u5230\u5f88\u597d\u7684\u8868\u5f81\uff0c\u5c24\u5176\u662f\u5728\u5927\u8111\u4e2d\u3002<\/p>\n

\u5728\u6b64\uff0c\u6211\u4eec\u5bf944\u540d\u6b7b\u4e8eCOVID-19\u7684\u60a3\u8005\u8fdb\u884c\u4e86\u5b8c\u6574\u7684\u5c38\u68c0\uff0c\u5e76\u5bf9\u5176\u4e2d11\u540d\u60a3\u8005\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u8fdb\u884c\u4e86\u5e7f\u6cdb\u91c7\u6837\uff0c\u4ee5\u7ed8\u5236\u548c\u91cf\u5316SARS-CoV-2\u5728\u6574\u4e2a\u4eba\u4f53\u5305\u62ec\u5927\u8111\u533a\u57df\u7684\u5206\u5e03\u3001\u590d\u5236\u548c\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\uff0c\u4ece\u6025\u6027\u611f\u67d3\u5230\u51fa\u73b0\u75c7\u72b6\u540e\u4e03\u4e2a\u591a\u6708\u3002<\/p>\n

\u7814\u7a76\u8868\u660e\uff0cSARS-CoV-2\u5206\u5e03\u5e7f\u6cdb\uff0c\u4e3b\u8981\u5206\u5e03\u5728\u6b7b\u4e8e\u91cd\u75c7COVID-19\u7684\u60a3\u8005\u4e2d\uff0c\u5e76\u4e14\u5728\u611f\u67d3\u65e9\u671f\uff0c\u75c5\u6bd2\u590d\u5236\u5b58\u5728\u4e8e\u591a\u79cd\u547c\u5438\u9053\u548c\u975e\u547c\u5438\u9053\u7ec4\u7ec7\u4e2d\uff0c\u5305\u62ec\u5927\u8111\u3002\u6b64\u5916\uff0c\u6211\u4eec\u5728\u591a\u4e2a\u89e3\u5256\u90e8\u4f4d\uff08\u5305\u62ec\u6574\u4e2a\u5927\u8111\uff09\u68c0\u6d4b\u5230\u6301\u7eed\u5b58\u5728\u7684SARS-CoV-2 RNA\uff0c\u5728\u4e00\u4e2a\u75c5\u4f8b\u4e2d\uff0c\u6700\u8fdf\u5728\u75c7\u72b6\u51fa\u73b0\u540e230\u5929\u3002\u5c3d\u7ba1SARS-CoV-2 RNA\u5728\u5168\u8eab\u5e7f\u6cdb\u5206\u5e03\uff0c\u4f46\u6211\u4eec\u51e0\u4e4e\u6ca1\u6709\u89c2\u5bdf\u5230\u547c\u5438\u9053\u5916\u708e\u75c7\u6216\u76f4\u63a5\u75c5\u6bd2\u7ec6\u80de\u75c5\u7406\u5b66\u7684\u8bc1\u636e\u3002<\/p>\n

\u6211\u4eec\u7684\u6570\u636e\u8868\u660e\uff0c\u5728\u67d0\u4e9b\u60a3\u8005\u4e2d\uff0cSARS-CoV-2\u53ef\u5f15\u8d77\u5168\u8eab\u611f\u67d3\u5e76\u5728\u4f53\u5185\u6301\u7eed\u6570\u6708\u3002<\/p>\n

\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u7ed3\u679c\u8868\u660e\uff0c\u5c3d\u7ba1SARS-CoV-2\u7684\u6700\u9ad8\u8d1f\u62c5\u662f\u5728\u547c\u5438\u9053\u7ec4\u7ec7\u4e2d\uff0c\u4f46\u8be5\u75c5\u6bd2\u53ef\u4ee5\u4f20\u64ad\u5230\u6574\u4e2a\u8eab\u4f53\u3002<\/p>\n

\u5c38\u68c0\u5bf9\u8fd9\u9879\u7814\u7a76\u6709\u8d21\u732e\u768444\u4eba\u90fd\u662f\u6b7b\u4e8eCOVID-19\u7684\u672a\u63a5\u79cd\u75ab\u82d7\u7684\u4eba\u3002\u8fd9\u4e9b\u4eba\u7684\u4e2d\u4f4d\u5e74\u9f84\u4e3a62.5\u5c81\uff0c61.4%\u7684\u4eba\u60a3\u6709\u4e09\u79cd\u6216\u4e09\u79cd\u4ee5\u4e0a\u7684\u5e76\u53d1\u75c7\u3002\u4ece\u51fa\u73b0\u75c7\u72b6\u5230\u60a3\u8005\u4f4f\u9662\u7684\u4e2d\u4f4d\u65f6\u95f4\u8de8\u5ea6\u4e3a6\u5929\uff0c\u4ece\u51fa\u73b0\u75c7\u72b6\u5230\u6b7b\u4ea1\u7684\u4e2d\u4f4d\u65f6\u95f4\u95f4\u9694\u4e3a18.5\u5929\u3002<\/p>\n

\u5c38\u68c0\u8868\u660e\uff0c\u8be5\u75c5\u6bd2\u80fd\u591f\u6e17\u900f\u5230\u8eab\u4f53\u7684\u8bb8\u591a\u7cfb\u7edf\u4e2d\uff0c\u5c3d\u7ba1\u7814\u7a76\u4eba\u5458\u6307\u51fa\uff0c\u5728\u547c\u5438\u9053\u7ec4\u7ec7\u4e2d\u53d1\u73b0\u7684SARS-CoV-2RNA\u8d1f\u62c5\u660e\u663e\u66f4\u9ad8\u3002\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u8be5\u75c5\u6bd2\u5df2\u7ecf\u4fb5\u5165\u4e86\u4f53\u5185\u4e0d\u540c\u7cfb\u7edf\u8d85\u8fc735\u79cd\u7ec6\u80de\u7c7b\u578b\u548c\u7ec6\u80de\u819c\u3002<\/p>\n

\u572844\u4f8b\u5c38\u68c0\u4e2d\uff0c\u670911\u4f8b\u662f\u5168\u8eab\u548c\u5927\u8111\u5c38\u68c0\uff0c\u63d0\u4f9b\u4e86\u75c5\u6bd2\u5728\u8fd9\u4e9b\u4e2a\u4f53\u4e2d\u4f20\u64ad\u7684\u6700\u5b8c\u6574\u60c5\u51b5\u300211\u4eba\u4e2d\uff0c\u75c7\u72b6\u53d1\u4f5c\u548c\u6b7b\u4ea1\u4e4b\u95f4\u7684\u6301\u7eed\u65f6\u95f4\u6700\u77ed\u7684\u4e24\u4eba\u5728\u5176\u547c\u5438\u7cfb\u7edf\u4e2d\u7684\u75c5\u6bd2RNA\u6c34\u5e73\u6700\u9ad8\uff0c\u5728\u5fc3\u8840\u7ba1\u7cfb\u7edf\u548c\u89c6\u795e\u7ecf\u7ec4\u7ec7\u7b49\u4e2d\u4e5f\u53d1\u73b0\u4e86\u9ad8\u6c34\u5e73\u7684\u75c5\u6bd2RNA\u3002<\/p>\n

\"\"<\/a>
\n\u3010\u70ed\u56fe\u63cf\u7ed8\u4e8611\u540d\u6b7b\u4e8eCOVID-19\u5e76\u63a5\u53d7\u5168\u8eab\u548c\u5927\u8111\u91c7\u6837\u7684\u60a3\u8005\u5c38\u68c0\u7ec4\u7ec7\u4e2d\u5b58\u5728\u7684\u901a\u8fc7ddPCR\u5bf9SARS-CoV-2 RNA (N) \u8fdb\u884c\u7684\u6700\u9ad8\u5e73\u5747\u91cf\u5316\u3002\u300a\u81ea\u7136\u300b\uff08(Nature)\u3011<\/p>\n

\u5728\u8fd9\u4e9b\u5c38\u4f53\u89e3\u5256\u768411\u4f8b\u4e2d\uff0c\u670910\u4f8b\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6216\u8111\u7ec4\u7ec7\u7684\u81f3\u5c11\u4e00\u4e2a\u5730\u65b9\u53d1\u73b0\u4e86\u75c5\u6bd2\u3002<\/p>\n

\u7814\u7a76\u4eba\u5458\u6307\u51fa\uff0c\u867d\u7136\u53d1\u73b0\u4e86\u91cd\u8981\u7684\u75c5\u6bd2\u75d5\u8ff9\uff0c\u4f46\u5927\u8111\u7684\u5b9e\u9645\u7ed3\u6784\u7ec4\u7ec7\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u6ca1\u6709\u88ab\u75c5\u6bd2\u6539\u53d8\u3002<\/p>\n

\u51fa\u73b0\u75c7\u72b6\u548c\u6b7b\u4ea1\u4e4b\u95f4\u6301\u7eed\u65f6\u95f4\u6700\u957f\u7684\u4eba\u662f230\u5929\uff0c\u5728\u4ed6\u8eab\u4f53\u5404\u4e2a\u90e8\u4f4d\u7684\u8bb8\u591a\u5730\u65b9\u90fd\u6709\u75c5\u6bd2\u75d5\u8ff9\uff0c\u5305\u62ec\u547c\u5438\u7cfb\u7edf\u3001\u5fc3\u810f\u3001\u773c\u7ec4\u7ec7\u548c\u5927\u8111\u3002<\/p>\n

\u7814\u7a76\u4eba\u5458\u6307\u51fa\uff0c\u8fd9\u8868\u660e\u8be5\u75c5\u6bd2\u53ef\u4ee5\u5728\u67d0\u4e9b\u60a3\u8005\u4f53\u5185\u9017\u7559\u6570\u6708\u3002<\/p>\n

\u6b7b\u4ea1\u539f\u56e0\u56e0\u4eba\u800c\u5f02\u300238\u4eba\u6b7b\u4e8eCOVID-19\uff0c\u800c6\u4eba\u5728\u611f\u67d3COVID-19\u65f6\u6b7b\u4e8e\u53e6\u4e00\u4e2a\u4e3b\u8981\u75be\u75c5\u3002\u5728\u6b7b\u4e8e\u8be5\u75c5\u6bd2\u7684\u4eba\u4e2d\uff0c\u670935\u4eba\u5728\u6b7b\u4ea1\u65f6\u60a3\u6709\u6025\u6027\u80ba\u708e\u6216\u4e25\u91cd\u80ba\u635f\u4f24\u3002<\/p>\n

\u5176\u4e2d\u4e24\u540d\u60a3\u8005\u53ea\u6709\u8f7b\u5fae\u7684COVID-19\u75c7\u72b6\u5e76\u4e14\u6b7b\u4e8e\u5176\u4ed6\u539f\u56e0\uff0c\u4f46\u4ecd\u88ab\u53d1\u73b0SARS-CoV-2RNA\u5728\u4ed6\u4eec\u7684\u5168\u8eab\u5e7f\u6cdb\u4f20\u64ad\uff0c\u8fd9\u8868\u660e\u5c3d\u7ba1\u5927\u90e8\u5206\u5c38\u68c0\u96c6\u4e2d\u5728\u91cd\u75c7\u548c\u5728\u81f4\u547d\u75c5\u4f8b\u4e2d\uff0c\u5373\u4f7f\u662f\u8f7b\u5ea6\u75c5\u4f8b\uff0c\u75c5\u6bd2\u4e5f\u80fd\u6df1\u5165\u4eba\u4f53\u3002<\/p>\n

\"\"<\/a>
\n\u3010\u56fe\u50cf\u663e\u793a\u4f4d\u4e8e\u9ad8\u5c14\u57fa\u4f53\u548c\u5185\u8d28\u7f51\uff08Golgi and endoplasmic reticulum\uff09\u7684 SARS-CoV-2 \u75c5\u6bd2\u653e\u5927 500 \u500d\uff0c\u5916\u89c2\u5448\u6838\u5468\u72b6\uff0c\u4f4d\u4e8e\u4ee5\u4e0b\u5668\u5b98\u4e2d\uff1a(a) \u7532\u72b6\u817a\uff0c(b) \u98df\u9053\uff0c(c) \u813e\u810f\uff0c(d) \u9611\u5c3e\uff0c(e) ) \u80be\u4e0a\u817a\uff0c(f) \u5375\u5de2\uff0c(g) \u777e\u4e38\uff0c(h) \u5b50\u5bab\u5185\u819c\u3002\u300a\u81ea\u7136\u300b\uff08(Nature)\u3011<\/p>\n

\u8be5\u7814\u7a76\u7684\u5c40\u9650\u6027\u5728\u4e8e\u5176\u8303\u56f4\u5c0f\uff0c\u5e76\u4e14\u91cd\u70b9\u5173\u6ce8\u6b7b\u4e8eCOVID-19\u7684\u672a\u63a5\u79cd\u75ab\u82d7\u7684\u8001\u5e74\u4eba\u3002<\/p>\n

\u5148\u524d\u7684\u5c38\u68c0\u7814\u7a76\u5df2\u7ecf\u5728\u591a\u4e2a\u7cfb\u7edf\u4e2d\u53d1\u73b0\u4e86COVID-19\u7684\u8bc1\u636e\uff0c\u7814\u7a76\u4eba\u5458\u8868\u793a\uff0c\u8fd9\u9879\u65b0\u7814\u7a76\u5728\u7ec6\u80de\u6c34\u5e73\u4e0a\u8bc1\u5b9e\u4e86SARS-CoV-2\u3002<\/p>\n

\u4f5c\u8005\u8868\u793a\uff0c\u4e86\u89e3SARS-CoV-2\u9003\u907f\u514d\u75ab\u68c0\u6d4b\u7684\u673a\u5236\u5bf9\u4e8e\u6307\u5bfc\u672a\u6765\u4fc3\u8fdb\u75c5\u6bd2\u6e05\u9664\u7684\u6cbb\u7597\u65b9\u6cd5\u81f3\u5173\u91cd\u8981\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\uff08\u661f\u661f\u751f\u6d3b\/\u6377\u514b\u4f73\uff092022\u5e7412\u6708\u53d1\u8868\u5728\u540c\u884c\u8bc4\u5ba1\u671f\u520a\u300a\u81ea\u7136\u300b\uff08(Nature)\u4e0a\u5bf9\u5c38\u68c0\u7ed3\u679c\u7684\u63cf\u8ff0\uff0c\u7a81\u51fa\u4e86\u611f\u67d3\u8d1f\u62c5\u7684\u6df1\u8fdc\u5f71\u54cd\uff0c\u572844\u540d\u60a3\u8005\u4f53\u518585\u4e2a\u90e8\u4f4d\u4e2d\u768479\u4e2a\u53d1\u73b0\u4e86\u75c5\u6bd2\u7247\u6bb5\u3002 44\u540dCOVID-19\u4ea1\u8005\u7684\u5c38\u68c0\u7ed3\u679c\u8868\u660e\uff0c\u75c5\u6bd2\u4e0d\u4ec5\u901a\u8fc7\u547c\u5438\u7cfb\u7edf\u4f20\u64ad\uff0c\u800c\u4e14\u8fd8\u901a\u8fc7\u6574\u4e2a\u8eab\u4f53\uff08\u5305\u62ec\u5927\u8111\uff09\u5728\u4e00\u4e9b\u60a3\u8005\u8eab\u4e0a\u6301\u7eed\u4f20\u64ad…
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