{"id":67312,"date":"2022-11-25T13:22:04","date_gmt":"2022-11-25T18:22:04","guid":{"rendered":"https:\/\/blog.jackjia.com\/?p=67312"},"modified":"2022-11-25T13:22:04","modified_gmt":"2022-11-25T18:22:04","slug":"20221125-%e5%a5%bd%e6%b6%88%e6%81%af%ef%bc%81%e9%92%88%e5%af%b9%e6%89%80%e6%9c%89%e5%b7%b2%e7%9f%a5%e6%b5%81%e6%84%9f%e7%97%85%e6%af%92%e6%a0%aa%e6%96%b0%e5%9e%8bmrna%e7%96%ab%e8%8b%97%e7%bb%bd","status":"publish","type":"post","link":"https:\/\/blog.jackjia.com\/?p=67312","title":{"rendered":"20221125\/\u597d\u6d88\u606f\uff01\u9488\u5bf9\u6240\u6709\u5df2\u77e5\u6d41\u611f\u75c5\u6bd2\u682a\u65b0\u578bmRNA\u75ab\u82d7\u7efd\u9732\u66d9\u5149"},"content":{"rendered":"<p>\uff08\u661f\u661f\u751f\u6d3b\/\u6377\u514b\u4f73\uff09\u4e00\u79cd\u4e00\u6b21\u6027\u9488\u5bf9\u6240\u6709\u5df2\u77e5\u6d41\u611f\u75c5\u6bd2\u682a\u7684\u65b0\u578bmRNA\u75ab\u82d7\u5728\u52a8\u7269\u7814\u7a76\u4e2d\u663e\u793a\u51fa\u65e9\u671f\u524d\u666f\uff0c\u5e76\u4e3a\u75ab\u82d7\u6280\u672f\u7684\u5e7f\u6cdb\u53ef\u80fd\u6027\u6253\u5f00\u4e86\u5927\u95e8\uff0c\u5305\u62ec\u53ef\u80fd\u9884\u9632\u4e0b\u4e00\u6b21\u6d41\u611f\u5927\u6d41\u884c\u3002<\/p>\n<p>\u7f8e\u56fd\u8d39\u57ce\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u5468\u56db\u5728\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u4ed6\u4eec\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u8868\u660e\u8be5\u75ab\u82d7\u5728\u5c0f\u9f20\u548c\u96ea\u8c82\u4e2d\u4ea7\u751f\u4e86\u9488\u5bf9\u6240\u6709\u6d41\u611f\u75c5\u6bd2\u682a\u7684\u9ad8\u6c34\u5e73\u6297\u4f53\u4fdd\u62a4\uff0c\u8fd9\u6709\u671d\u4e00\u65e5\u53ef\u80fd\u6709\u52a9\u4e8e\u4e3a\u901a\u7528\u63a5\u79cd\u6d41\u611f\u75ab\u82d7\u94fa\u5e73\u9053\u8def\u3002<\/p>\n<p><a href=\"http:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/science1125_1.png\"><img loading=\"lazy\" src=\"http:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/science1125_1.png\" alt=\"\" width=\"771\" height=\"370\" class=\"aligncenter size-full wp-image-67313\" srcset=\"https:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/science1125_1.png 771w, https:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/science1125_1-300x144.png 300w, https:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/science1125_1-768x369.png 768w\" sizes=\"(max-width: 771px) 100vw, 771px\" \/><\/a><\/p>\n<p><a href=\"http:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/science1125_2.png\"><img loading=\"lazy\" src=\"http:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/science1125_2.png\" alt=\"\" width=\"669\" height=\"397\" class=\"aligncenter size-large wp-image-67314\" srcset=\"https:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/science1125_2.png 669w, 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Hensley\u8bf4\uff1a\u201c\u6211\u4eec\u7684\u65b9\u6cd5\u662f\u5236\u9020\u4e00\u79cd\u75ab\u82d7\uff0c\u7f16\u7801\u6211\u4eec\u6240\u77e5\u9053\u7684\u6bcf\u4e00\u79cd\u6d41\u611f\u4e9a\u578b\u548c\u8c31\u7cfb\u3002\u201d<\/p>\n<p>\u201c\u6211\u4eec\u7684\u76ee\u6807\u662f\u5efa\u7acb\u4e00\u4e2a\u57fa\u7ebf\u6c34\u5e73\u7684\u514d\u75ab\u8bb0\u5fc6\uff0c\u7136\u540e\u5728\u51fa\u73b0\u65b0\u7684\u5927\u6d41\u884c\u6bd2\u682a\u65f6\u53ef\u4ee5\u5c06\u5176\u53ec\u56de\u3002\u201d<\/p>\n<p>\u5b63\u8282\u6027\u6d41\u611f\u75ab\u82d7\u6bcf\u5e74\u90fd\u53ef\u4ee5\u9884\u9632\u73b0\u6709\u7684\u518d\u6b21\u51fa\u73b0\u7684\u6bd2\u682a\uff0c\u4f46\u5bf9\u53ef\u80fd\u4ece\u52a8\u7269\u8eab\u4e0a\u51fa\u73b0\u5e76\u5f15\u53d1\u5927\u6d41\u884c\u7684\u6bd2\u682a\u51e0\u4e4e\u6ca1\u6709\u4fdd\u62a4\u4f5c\u7528\uff0c\u4f8b\u59822009\u5e74\u7684H1N1\uff0c\u4e0e\u6b64\u4e0d\u540c\u7684\u662f\uff0c\u8fd9\u79cd\u75ab\u82d7\u7406\u8bba\u4e0a\u53ef\u4ee5\u63d0\u4f9b\u9488\u5bf9\u6240\u6709\u65b0\u6d41\u611f\u6bd2\u682a\u7684\u514d\u75ab\u529b\u3002<\/p>\n<p><a href=\"http:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/cbc1125_1.png\"><img loading=\"lazy\" src=\"http:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/cbc1125_1.png\" alt=\"\" width=\"721\" height=\"483\" class=\"aligncenter size-full wp-image-67315\" srcset=\"https:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/cbc1125_1.png 721w, https:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/cbc1125_1-300x201.png 300w\" sizes=\"(max-width: 721px) 100vw, 721px\" \/><\/a><\/p>\n<p>\u201c\u73b0\u9636\u6bb5\u4ecd\u5904\u4e8e\u4e34\u5e8a\u524d\u6d4b\u8bd5\u9636\u6bb5\uff0c\u6211\u4eec\u6b63\u8ba1\u5212\u8fdb\u884c1\u671f\u4eba\u4f53\u7814\u7a76\uff0c\u4f46\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u4ece\u52a8\u7269\u6a21\u578b\u6765\u770b\uff0c\u8fd9\u79cd\u75ab\u82d7\u786e\u5b9e\u5b9e\u73b0\u4e86\u6211\u4eec\u5e7f\u6cdb\u8bf1\u5bfc\u514d\u75ab\u8bb0\u5fc6\u7684\u76ee\u6807\uff0c\u201dHensley\u8bf4\u3002<\/p>\n<p>\u201c\u60f3\u8c61\u4e00\u4e0b\uff0c\u5982\u679c\u4eba\u4eec\u63a5\u79cd\u4e86\u8fd9\u79cd\u75ab\u82d7\uff0c\u6211\u4eec\u53ef\u80fd\u770b\u5230\u7684\u4e0d\u4e00\u5b9a\u662f\u9632\u6b62\u611f\u67d3\u65b0\u7684\u5927\u6d41\u884c\u6bd2\u682a\uff0c\u800c\u662f\u51cf\u5c11\u4f4f\u9662\u548c\u4e25\u91cd\u75be\u75c5\uff0c\u8fd9\u624d\u662f\u6211\u4eec\u7684\u4e3b\u8981\u76ee\u6807\u3002\u201d<\/p>\n<p>\u867d\u7136\u6f5c\u5728\u7684\u75ab\u82d7\u53ef\u80fd\u8fd8\u9700\u8981\u6570\u5e74\u65f6\u95f4\u624d\u80fd\u6210\u529f\u901a\u8fc7\u4eba\u4f53\u8bd5\u9a8c\uff0c\u4f46\u5f00\u53d1\u51fa\u4e00\u79cd\u53ef\u4ee5\u9488\u5bf9\u6240\u670920\u79cd\u5df2\u77e5\u7684\u7532\u578b\u548c\u4e59\u578b\u6d41\u611f\u6bd2\u682a\u7684\u6d41\u611f\u75ab\u82d7\u662f\u4e00\u9879\u60ca\u4eba\u7684\u79d1\u5b66\u58ee\u4e3e\u3002<\/p>\n<p>\u8428\u65af\u5580\u5f7b\u6e29\u5927\u5b66\u75ab\u82d7\u548c\u4f20\u67d3\u75c5\u7ec4\u7ec7\u7684\u75c5\u6bd2\u5b66\u5bb6Alyson Kelvin\u8bf4\uff1a\u201c\u8fd9\u786e\u5b9e\u8868\u660e\u6211\u4eec\u53ef\u4ee5\u7528\u4ee5\u524d\u4ece\u672a\u60f3\u8fc7\u7684\u65b9\u5f0f\u4f7f\u7528mRNA\u75ab\u82d7\u3002\u201d Kelvin\u4e0e\u4ed6\u4eba\u5171\u540c\u64b0\u5199\u4e86\u5bf9\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u7814\u7a76\u7684\u72ec\u7acb\u89c2\u70b9\u3002<\/p>\n<p>\u201c\u8fd9\u53ea\u662f\u6211\u4eec\u53ef\u4ee5\u63a5\u79cd\u57fa\u4e8emRNA\u7684\u75ab\u82d7\u7684\u5f00\u59cb\u3002\u201d<\/p>\n<p>\u8be5\u7814\u7a76\u4e3amRNA\u75ab\u82d7\u6280\u672f\u5f00\u8f9f\u4e86\u4e00\u4e2a\u5145\u6ee1\u65b0\u53ef\u80fd\u6027\u7684\u4e16\u754c\u3002\u5982\u679c\u5b83\u901a\u8fc7\u4e34\u5e8a\u8bd5\u9a8c\u548c\u76d1\u7ba1\u6279\u51c6\uff0c\u5b83\u4e5f\u5e26\u6765\u4e86\u5e0c\u671b\uff0c\u6709\u671d\u4e00\u65e5\u53ef\u4ee5\u5728\u5168\u7403\u8303\u56f4\u5185\u9632\u6b62\u6570\u5341\u4e07\u4eba\u56e0\u6d41\u611f\u800c\u4f4f\u9662\u548c\u6b7b\u4ea1\u3002<\/p>\n<p>Kelvin\u8bf4\uff1a\u201c\u8fd9\u662f\u4e00\u79cd\u6db5\u76d6\u6bcf\u5e74\u5728\u4e16\u754c\u8303\u56f4\u5185\u9020\u6210\u5927\u91cf\u75be\u75c5\u8d1f\u62c5\u7684\u5e9e\u5927\u75c5\u6bd2\u5bb6\u65cf\u7684\u65b9\u6cd5\u3002\u6b64\u5916\uff0c\u65b0\u578b\u6d41\u611f\u75c5\u6bd2\u4e0d\u65ad\u8513\u5ef6\u7684\u5a01\u80c1\u65e0\u4f11\u6b62\u3002\u56e0\u6b64\uff0c\u5b83\u4e0d\u4ec5\u6db5\u76d6\u4e86\u6211\u4eec\u76ee\u524d\u6b63\u5728\u5904\u7406\u7684\u75c5\u6bd2\uff0c\u8fd8\u6db5\u76d6\u4e86\u6211\u4eec\u4e0d\u77e5\u9053\u7684\u75c5\u6bd2\u3002\u201d<\/p>\n<p>Kelvin\u8bf4\uff0c\u5173\u4e8e\u75ab\u82d7\u7684\u7814\u53d1\u4ee5\u786e\u4fdd\u5176\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5b89\u5168\u6709\u6548\uff0c\u4ecd\u6709\u4e00\u4e9b\u5173\u952e\u7684\u672a\u89e3\u4e4b\u8c1c\uff0c\u4f46\u52a8\u7269\u80fd\u591f\u5bf9\u6bcf\u79cd\u6bd2\u682a\u4ea7\u751f\u5f3a\u70c8\u800c\u72ec\u7279\u7684\u514d\u75ab\u53cd\u5e94\u8fd9\u4e00\u4e8b\u5b9e\u975e\u5e38\u6709\u5e0c\u671b\u3002<\/p>\n<p>\u5fb7\u514b\u8428\u65af\u5927\u5b66\u52a0\u5c14\u7ef4\u65af\u987f\u56fd\u5bb6\u5b9e\u9a8c\u5ba4\u4e3b\u4efbGary Kobinger\u8bf4\uff1a\u201c\u5b83\u786e\u5b9e\u4f7f\u8fd9\u79cd\u7b56\u7565\u4e0d\u4ec5\u4ec5\u662f\u8e0f\u8fdb\u4e86\u4e34\u5e8a\u5e94\u7528\u7684\u5927\u95e8\uff0c\u6211\u60f3\u8bf4\u662f\u5b8c\u5168\u8e0f\u8fdb\u4e86\u5927\u95e8\u3002\u201dKobinger\u5e2e\u52a9\u5f00\u53d1\u4e86\u52a0\u62ff\u5927\u4e3b\u5bfc\u7684\u57c3\u535a\u62c9\u75ab\u82d7\u3002<\/p>\n<p>\u201c\u8fd9\u662f\u4e00\u7bc7\u5173\u4e8e\u52a8\u7269\u7684\u79d1\u5b66\u8bba\u6587\u4e4b\u4e00\uff0c\u8fd9\u53ef\u80fd\u5c06\u4f1a\u5728\u4eba\u7c7b\u8eab\u4e0a\u53d1\u751f\uff0c\u8fd9\u662f\u4e00\u4e2a\u77ed\u671f\u5230\u4e2d\u671f\u7684\u65f6\u95f4\u8868\uff0c\u201d\u4ed6\u8865\u5145\u8bf4\u3002\u201c\u6240\u4ee5\u8ba9\u6211\u4eec\u770b\u770b\u8fd9\u662f\u5426\u6709\u6548\u3002\u6211\u4eec\u90fd\u5e0c\u671b\u5b83\u4f1a\u3002\u201d<\/p>\n<p><a href=\"http:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/cbc1125_2.png\"><img loading=\"lazy\" src=\"http:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/cbc1125_2.png\" alt=\"\" width=\"716\" height=\"460\" class=\"aligncenter size-large wp-image-67316\" srcset=\"https:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/cbc1125_2.png 716w, https:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/cbc1125_2-300x193.png 300w\" sizes=\"(max-width: 716px) 100vw, 716px\" \/><\/a><\/p>\n<p>\u8be5\u75ab\u82d7\u4f7f\u7528\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\uff08lipid nanoparticles\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u6210\u529f\u7684mRNA\u75ab\u82d7\u9012\u9001\u7cfb\u7edf\uff0c\u7531\u52a0\u62ff\u5927\u79d1\u5b66\u5bb6Pieter 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href=\"http:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/cbc1125_4.png\"><img loading=\"lazy\" src=\"http:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/cbc1125_4.png\" alt=\"\" width=\"707\" height=\"402\" class=\"aligncenter size-large wp-image-67318\" srcset=\"https:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/cbc1125_4.png 707w, https:\/\/blog.jackjia.com\/wp-content\/uploads\/2022\/11\/cbc1125_4-300x171.png 300w\" sizes=\"(max-width: 707px) 100vw, 707px\" 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\u7f8e\u56fd\u8d39\u57ce\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u5468\u56db\u5728\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u4ed6\u4eec\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u8868\u660e\u8be5\u75ab\u82d7\u5728\u5c0f\u9f20\u548c\u96ea\u8c82\u4e2d\u4ea7\u751f\u4e86\u9488\u5bf9\u6240\u6709\u6d41\u611f\u75c5\u6bd2\u682a\u7684\u9ad8\u6c34\u5e73\u6297\u4f53&#8230;<br \/><a class=\"read-more-button\" href=\"https:\/\/blog.jackjia.com\/?p=67312\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":67317,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=\/wp\/v2\/posts\/67312"}],"collection":[{"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=67312"}],"version-history":[{"count":1,"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=\/wp\/v2\/posts\/67312\/revisions"}],"predecessor-version":[{"id":67319,"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=\/wp\/v2\/posts\/67312\/revisions\/67319"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=\/wp\/v2\/media\/67317"}],"wp:attachment":[{"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=67312"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=67312"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=67312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}