{"id":57828,"date":"2020-04-11T22:43:08","date_gmt":"2020-04-12T03:43:08","guid":{"rendered":"http:\/\/blog.jackjia.com\/?p=57828"},"modified":"2020-04-11T22:44:50","modified_gmt":"2020-04-12T03:44:50","slug":"20200411%e5%ad%a6%e6%9c%af%e9%97%ae%e9%a2%98%e6%97%a0%e9%9c%80%e6%94%bf%e6%b2%bb%e5%8c%96%ef%bc%8c%e5%8a%a0%e6%8b%bf%e5%a4%a7%e4%b8%93%e5%ae%b6%e5%ad%a6%e8%80%85%e8%a7%a3%e8%af%bbpnas%e6%9c%80","status":"publish","type":"post","link":"https:\/\/blog.jackjia.com\/?p=57828","title":{"rendered":"20200411\/\u5b66\u672f\u95ee\u9898\u65e0\u9700\u653f\u6cbb\u5316\uff0c\u52a0\u62ff\u5927\u4e13\u5bb6\u5b66\u8005\u89e3\u8bfbPNAS\u6700\u65b0\u8bba\u6587"},"content":{"rendered":"

\uff08\u661f\u661f\u751f\u6d3b\u8bb0\u8005\u6377\u514b\u4f73\u62a5\u9053\uff09\u5b66\u672f\u754c\u9887\u5177\u5f71\u54cd\u529b\u7684\u56fd\u9645\u671f\u520aPNAS\u65e5\u524d\u53d1\u8868\u6709\u5173\u65b0\u51a0\u75c5\u6bd2\u6eaf\u6e90\u7684\u6700\u65b0\u7814\u7a76\u6210\u679c\uff0c\u5728\u8206\u8bba\u573a\u53c8\u6380\u8d77\u9635\u9635\u6d9f\u6f2a\u3002\u53d7\u8bbf\u7684\u52a0\u62ff\u5927\u4e13\u5bb6\u5b66\u8005\u8ba4\u4e3a\uff0c\u6587\u7ae0\u7684\u8bba\u70b9\u4e0e\u7ed3\u8bba\u4ecd\u5c5e\u4e8e\u5b66\u672f\u8303\u7574\uff0c\u65e0\u9700\u653f\u6cbb\u5316\u8fc7\u5ea6\u89e3\u8bfb\uff0c\u4e0e\u9634\u8c0b\u8bba\u6ca1\u6709\u4efb\u4f55\u5173\u7cfb\u3002<\/p>\n

PNAS\u662f\u300a\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a\u300b\u3002\u81ea1914\u5e74\u521b\u520a\u81f3\u4eca\uff0cPNAS\u63d0\u4f9b\u5177\u6709\u9ad8\u6c34\u5e73\u7684\u524d\u6cbf\u7814\u7a76\u62a5\u544a\u3001\u5b66\u672f\u8bc4\u8bba\u3001\u5b66\u79d1\u56de\u987e\u53ca\u524d\u77bb\u3001\u5b66\u672f\u8bba\u6587\u4ee5\u53ca\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u5b66\u4f1a\u5b66\u672f\u52a8\u6001\u7684\u62a5\u9053\u548c\u51fa\u7248\u3002<\/p>\n

2020\u5e744\u67088\u65e5\uff0cPNAS\u53d1\u8868\u9898\u4e3a\u201cSARS-CoV-2\u57fa\u56e0\u7ec4\u7684\u7cfb\u7edf\u8fdb\u5316\u7f51\u7edc\u5206\u6790\u201d\uff08Phylogenetic network analysis of SARS-CoV-2 genomes\uff09\u7684\u8bba\u6587\u3002\u4f5c\u8005\u5206\u522b\u6765\u81ea\u5fb7\u56fd\u548c\u82f1\u56fd\u7684\u7814\u7a76\u673a\u6784\u4e0e\u9ad8\u6821\u3002<\/p>\n

\"\"<\/a>
\n\u3010\u56fe\u4e3aPNAS\u53d1\u8868\u7684\u8bba\u6587\u201cSARS-CoV-2\u57fa\u56e0\u7ec4\u7684\u7cfb\u7edf\u8fdb\u5316\u7f51\u7edc\u5206\u6790\u201d\u3002\u56fe\u6e90\uff1aPNAS\u7f51\u7ad9\u622a\u56fe\u3011<\/p>\n

\u6839\u636e\u8bba\u6587\u5185\u5bb9\uff0c\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u5206\u6790\u4ece\u4e16\u754c\u5404\u5730\u91c7\u96c6\u7684160\u4e2a\u5b8c\u6574\u75c5\u6bd2\u57fa\u56e0\u7ec4\u6570\u636e\uff0c\u53d1\u73b0\u65b0\u51a0\u75c5\u6bd2\u4e09\u4e2a\u4ee5\u6c28\u57fa\u9178\u53d8\u5316\u4e3a\u7279\u5f81\u7684\u201c\u53d8\u79cd\u201d\uff0c\u5c06\u5176\u5f62\u6001\u5206\u522b\u6807\u8bb0\u4e3aA\u3001B\u548cC\u3002\u5176\u4e2dA\u4e3a\u6839\u636e\u8759\u8760\u7684\u7956\u5148\u578b\u51a0\u72b6\u75c5\u6bd2\uff0c\u7814\u7a76\u4eba\u5458\u79f0\u5176\u4e3a\u66f4\u63a5\u8fd1\u4e8e\u75c5\u6bd2\u7684\u8d77\u6e90\uff0c\u800c\u6b27\u6d32\u4e3b\u8981\u7c7b\u578bC\u7c7b\u53c8\u6765\u81ea\u4e8eB\u7c7b\u3002A\u578b\u548cC\u578b\u5728\u4e1c\u4e9a\u4ee5\u5916\u5730\u533a\uff08\u5373\u6b27\u6d32\u4eba\u548c\u7f8e\u56fd\u4eba\u4e2d\uff09\u7684\u6bd4\u4f8b\u5f88\u9ad8\u3002 \u76f8\u6bd4\u4e4b\u4e0b\uff0cB\u578b\u662f\u4e1c\u4e9a\u6700\u5e38\u89c1\u7684\u7c7b\u578b\uff0c\u6ca1\u6709\u5728\u4e1c\u4e9a\u4ee5\u5916\u4f20\u64ad\u3002<\/p>\n

\"\"<\/a>
\n\u3010\u56fe\u4e3a\u8bba\u6587\u6458\u8981\u3002\u56fe\u6e90\uff1aPNAS\u7f51\u7ad9\u622a\u56fe\u3011<\/p>\n

\u76ee\u524d\u5c31\u804c\u4e8e\u52a0\u62ff\u5927\u56fd\u5bb6\u79d1\u5b66\u9662\u8425\u517b\u536b\u751f\u548c\u5065\u5eb7\u7814\u7a76\u6240\u7684\u738b\u6839\u535a\u58eb\u5411\u661f\u661f\u751f\u6d3b\u8bb0\u8005\u8868\u793a\uff0c\u73b0\u5728\u4eba\u4eec\u559c\u6b22\u901a\u8fc7\u201c\u6cdb\u57fa\u56e0\u5316\u201d\u6765\u89e3\u91ca\u8fdb\u5316\uff0c\u4f46\u7528\u7cfb\u7edf\u8fdb\u5316\u6811\u8fd9\u4e00\u5206\u6790\u65b9\u6cd5\u672c\u8eab\u5c31\u5b58\u5728\u7740\u4e00\u5b9a\u7684\u5047\u8bbe\uff0c\u800c\u4e14\u8fd8\u6709\u5404\u4e2a\u56fd\u5bb6\u6536\u96c6\u7684\u6837\u672c\u5bb9\u91cf\u3002\u56e0\u6b64\uff0c\u6587\u7ae0\u7684\u8bba\u70b9\u4e0e\u7ed3\u8bba\u4ecd\u5c5e\u4e8e\u5b66\u672f\u8303\u7574\u3002<\/p>\n

\"\"<\/a>
\n\u3010\u56fe\u4e3a\u53d7\u8bbf\u8005\u738b\u6839\u535a\u58eb\u3002\u8d44\u6599\u56fe\u3011<\/p>\n

\u591a\u5e74\u524d\u738b\u6839\u66fe\u7ecf\u4ece\u4e8b\u5206\u5b50\u75c5\u6bd2\u5b66\u7684\u7814\u7a76\u3002\u4ed6\u89e3\u91ca\u8bf4\uff0c\u7cfb\u7edf\u8fdb\u5316\u6811\u7ecf\u5e38\u88ab\u7528\u4e8e\u5206\u6790\u8840\u7f18\u5173\u7cfb\uff0c\u5b8c\u5168\u57fa\u4e8e\u57fa\u56e0\u5e8f\u5217\u3002\u8bfb\u535a\u671f\u95f4\uff0c\u4ed6\u5728\u5206\u6790\u75c5\u6bd2\u8fdb\u5316\u5173\u7cfb\u65f6\u4e5f\u7528\u8fc7\u8be5\u65b9\u6cd5\u30021998\u5e74\u5728\u829d\u52a0\u54e5\u533b\u5b66\u9662\u7684\u4e00\u4e2a\u5408\u4f5c\u9879\u76ee\u4e2d \uff0c\u4ed6\u8d1f\u8d23\u81ea\u52a8\u6d4b\u5e8f\uff0c\u6d4b\u5b9a\u4e16\u754c\u4e0a\u4f17\u591a\u682a\u827e\u6ecb\u75c5\u7684\u75c5\u6bd2\u57fa\u56e0\u5e8f\u5217\u4e2d\u7684\u4e00\u4e2a\u7ed3\u6784\u86cb\u767d\u57fa\u56e0\u5e8f\u5217\u3002\u6700\u540e\u5f97\u51fa\u7ed3\u8bba\uff0c\u4eba\u662f\u4ece\u7334\u5b50\u8eab\u4e0a\u6765\u7684\uff0c\u9ed1\u7329\u7329\u53ef\u80fd\u6027\u6700\u5927\u3002<\/p>\n

\u8457\u540d\u6d41\u884c\u75c5\u4e13\u5bb6\u3001\u52a0\u62ff\u5927\u7ebd\u82ac\u5170\u5927\u5b66\u533b\u5b66\u9662\u7ec8\u8eab\u6559\u6388\u738b\u57f9\u5fe0\u5728\u4ed4\u7ec6\u9605\u8bfb\u8fc7\u8be5\u7bc7\u8bba\u6587\u540e\u8ba4\u4e3a\uff0c\u8fd9\u7eaf\u7cb9\u662f\u4e00\u4e2a\u5b66\u672f\u95ee\u9898\uff0c\u8ddf\u9634\u8c0b\u8bba\u5b9e\u9645\u4e0a\u6ca1\u6709\u4efb\u4f55\u5173\u7cfb\u3002<\/p>\n

\"\"<\/a>
\n\u3010\u56fe\u4e3a\u53d7\u8bbf\u8005\u738b\u57f9\u5fe0\u6559\u6388\u3002\u8d44\u6599\u56fe\u3011<\/p>\n

\u738b\u57f9\u5fe0\u4ecb\u7ecd\u8bf4\uff0c\u7528\u9057\u4f20\u7f51\u7edc\u5206\u6790\uff08genetic network analysis\uff09\u8fd9\u4e2a\u65b9\u6cd5\u6bd4\u8f83\u5e38\u89c1\uff0c\u5c31\u662f\u6309Cluster\uff08\u96c6\u7fa4\uff09\u5206\u6790\u3002\u6839\u636e\u6587\u7ae0\u63d0\u4f9b\u7684\u56fe\u89e3\uff0c\u5f88\u660e\u786e\u7f8e\u56fd\u7684Cluster\u662f\u5728\u6b66\u6c49\u7206\u53d1\u4e4b\u540e\u3002\u4f5c\u8005\u5728\u7528\u8fd9\u4e00\u5206\u6790\u65b9\u6cd5\u7684\u524d\u63d0\u5df2\u7ecf\u786e\u5b9a\u662f\u5728\u6b66\u6c49\u5f00\u59cb\u7684\uff08Primary node, \u5927\u9ec4\u70b9\uff09\uff0c \u5e76\u6b64\u57fa\u7840\u4e0a\u5f62\u6210\u82e5\u5e72\u5b50Clusters\u3002<\/p>\n

\u738b\u57f9\u5fe0\u8bf4\uff0c\u5176\u6838\u5fc3\u610f\u601d\u8bf4\u5c3d\u7ba1A\u539f\u59cb\u578b\u5728\u4e2d\u56fd\u5b58\u5728\u4f46\u6ca1\u5f15\u8d77\u4f20\u64ad\uff0c\u76f8\u53cd\u5176\u53d8\u5f02\u578bB\u578b\u662f\u4e3b\u8981\u7684\u3002\u7f8e\u56fd\u4eba1\u670820\u5728\u4e2d\u56fd\u6b66\u6c49\u611f\u67d3\u540e\u56de\u7f8e\u56fd\u3002\u4ece\u4f5c\u8005\u63d0\u4f9b\u7684\u53c2\u8003\u6587\u732e\u539f\u6587\u4e0e\u5173\u8054\u56fe\u4f1a\u66f4\u6e05\u695a\u3002\u5176\u539f\u6587\u8868\u8ff0\u662f\uff1a”The first known case of COVID-19 in the U.S. was confirmed on January 20, 2020, in a 35-year-old returnee from Wuhan, China, five days earlier.” <\/p>\n

\"\"<\/a>
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\u4ed6\u6307\u51fa\uff0c\u76ee\u524d\u56fd\u9645\u793e\u4f1a\u547c\u5401\u7684\u8c03\u67e5\uff0c\u4e0e\u79d1\u5b66\u52a0\u63a2\u7d22\u6e90\u5934\u4e0d\u4e00\u6837\uff0c\u524d\u8005\u4e3b\u8981\u662f\u5426\u6709\u4eba\u4e3a\u56e0\u7d20\u5bfc\u81f4\u6700\u521d\u7684\u63a7\u5236\u4e0d\u5229\uff0c\u53ca\u4e4b\u540e\u66f4\u5927\u7684\u7206\u53d1\u6d41\u884c\u3002\u800c\u63a2\u7d22\u6240\u6e90\u5934\u76ee\u7684\u662f\u66f4\u597d\u4e86\u89e3\u53ca\u5982\u4f55\u51cf\u5c11\u5176\u53d1\u751f\u3002<\/p>\n

\u201c\u7814\u7a76\u4eba\u5458\u8bd5\u56fe\u5bfb\u627e\u7684\u662f\u4eba\u7c7b\u5065\u5eb7\u7cfb\u7edf\u7684\u6f0f\u6d1e\uff0c\u4f46\u628a\u5b66\u672f\u95ee\u9898\u653f\u6cbb\u5316\uff0c\u5f88\u53ef\u6015\u3002\u201d\u738b\u57f9\u5fe0\u5f3a\u8c03\u8bf4\u3002<\/p>\n

\u6b64\u5916\uff0c\u7531\u738b\u57f9\u5fe0\u9886\u8854\u5305\u62ec\u591a\u4f4d\u534e\u88d4\u5b66\u8005\u4e3b\u6301\u7684\u4e00\u9879\u5173\u4e8e\u5bf9\u65b0\u51a0\u75c5\u6bd2\u8ba4\u77e5\u8c03\u67e5\u521d\u6b65\u62a5\u544a\u8fd1\u65e5\u51fa\u7089\uff0c\u5176\u7814\u7a76\u6210\u679c\u5bf9\u4e86\u89e3\u534e\u4eba\u5bf9COVID-19\u8ba4\u8bc6\u53ca\u5065\u5eb7\u884c\u4e3a\u7684\u53ca\u65f6\u4e86\u89e3\uff0c\u5bf9\u63a7\u5236\u75ab\u60c5\u6709\u91cd\u8981\u610f\u4e49\u3002<\/p>\n

\uff08\u89c1\u53e6\u6587\uff1a\u52a0\u62ff\u5927\u534e\u4eba\u5bf9\u65b0\u51a0\u75c5\u6bd2\u8ba4\u77e5\u8c03\u67e5\u521d\u6b65\u62a5\u544a\u51fa\u7089<\/a> http:\/\/newstar.superlife.ca\/?p=273104\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

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