{"id":53173,"date":"2018-11-30T16:44:02","date_gmt":"2018-11-30T21:44:02","guid":{"rendered":"http:\/\/blog.jackjia.com\/?p=53173"},"modified":"2018-11-30T17:00:40","modified_gmt":"2018-11-30T22:00:40","slug":"20181130%e8%bd%ac%e5%9f%ba%e5%9b%a0%e5%a9%b4%e5%84%bf%e7%9a%84%e8%b5%84%e6%9c%ac%e8%bf%b7%e9%9b%be-%e6%b7%b1%e5%9c%b3%e7%9a%84%e9%ad%94%e9%ac%bc%e5%90%b9%e7%ac%9b%e4%ba%ba","status":"publish","type":"post","link":"https:\/\/blog.jackjia.com\/?p=53173","title":{"rendered":"20181130\/\u8f6c\u57fa\u56e0\u5a74\u513f\u7684\u8d44\u672c\u8ff7\u96fe \u6df1\u5733\u7684\u201c\u9b54\u9b3c\u5439\u7b1b\u4eba\u201d"},"content":{"rendered":"

\u6765\u6e90\uff1a\u683c\u9686\u6c47<\/p>\n

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\uff08\u4e00\uff09\u9a87\u4e16\u60ca\u4fd7\u7684\u8d3a\u6559\u6388<\/strong><\/p>\n

11\u670826\u65e5\uff0c\u4eba\u6c11\u7f51\u6df1\u5733\u9891\u9053\u9996\u53d1\u62a5\u9053\uff0c\u79f0\u4e00\u5bf9\u540d\u4e3a\u9732\u9732\u548c\u5a1c\u5a1c\u7684\u53cc\u80de\u80ce\u5973\u5a74\u5df2\u4e8e\u672c\u6708\u5728\u4e2d\u56fd\u6df1\u5733\u5065\u5eb7\u8bde\u751f\u3002\u7279\u6b8a\u7684\u662f\uff0c\u4ed6\u4eec\u662f\u4e16\u754c\u9996\u4f8b\u514d\u75ab\u827e\u6ecb\u75c5\u7684\u201c\u57fa\u56e0\u7f16\u8f91\u5a74\u513f\u201d\u3002<\/p>\n

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\"\"<\/a><\/p>\n

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2012\u5e74\u76841\u6708\uff0c\u8d3a\u5efa\u594e\u7ecf\u6df1\u5733\u5e02\u201c\u5b54\u96c0\u8ba1\u5212\u201d\u6d77\u5916\u9ad8\u5c42\u6b21\u4eba\u624d\u8ba1\u5212\u5f15\u8fdb\u56de\u56fd\uff0c\u6325\u522b\u751f\u6d3b\u4e94\u5e74\u7684\u7f8e\u56fd\uff0c\u6765\u5230\u4e86\u5357\u65b9\u79d1\u6280\u5927\u5b66\uff0c\u4e3b\u8981\u7814\u7a76\u65b9\u5411\u662f\u514d\u75ab\u7ec4\u5e93\u6d4b\u5e8f\u3001\u4e2a\u4f53\u5316\u533b\u7597\u3001\u751f\u7269\u4fe1\u606f\u5b66\u548c\u7cfb\u7edf\u751f\u7269\u5b66\u3002\uff08\u6458\u81ea\u817e\u8baf\u754c\u9762\uff09<\/p>\n

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\"\"<\/a><\/p>\n

\u8fd9\u4e2a\u6280\u672f\u5e76\u4e0d\u65b0\u9896\uff0c2015\u5e744\u6708\uff0c\u4e2d\u5c71\u5927\u5b66\u6559\u6388\u9ec4\u519b\u5c31\u53d1\u8868\u8bba\u6587\uff0c\u5ba3\u5e03\u5229\u7528CRISPR-Cas9\u6280\u672f\u8bd5\u56fe\u4fee\u6539\u4eba\u7c7b\u80da\u80ce\u4e2d\u7684\u4e00\u4e2a\u81f4\u75c5\u57fa\u56e0\u3002\u4e0d\u8fc7\u5176\u7814\u7a76\u5bf9\u8c61\u662f\u8f85\u52a9\u751f\u6b96\u6280\u672f\u4e0b\u4ea7\u751f\u7684\u4f53\u5916\u5269\u4f59\u80da\u80ce\uff0c\u7c7b\u578b\u4e3a\u4e0d\u53ef\u80fd\u53d1\u80b2\u4e3a\u6210\u719f\u4e2a\u4f53\u7684\u4e09\u5143\u6838\u5408\u5b50\u3002<\/p>\n

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\u95ee\u9898\u662f\u975e\u5e38\u4e25\u91cd\u7684\uff0c122\u4f4d\u79d1\u5b66\u5bb6\u5728\u5fae\u535a\u53d1\u5e03\u7684\u8054\u5408\u58f0\u660e\u5f88\u6709\u4ee3\u8868\u6027\uff1a\u201c\u8fd9\u9879\u6240\u8c13\u7814\u7a76\u7684\u751f\u7269\u533b\u5b66\u4f26\u7406\u5ba1\u67e5\u5f62\u540c\u865a\u8bbe\u3002\u6b64\u9879\u6280\u672f\u65e9\u5c31\u53ef\u4ee5\u505a\uff0c\u6ca1\u6709\u4efb\u4f55\u521b\u65b0\uff0c\u4f46\u662f\u5168\u7403\u7684\u751f\u7269\u533b\u5b66\u79d1\u5b66\u5bb6\u4eec\u4e0d\u53bb\u505a\u3001\u4e0d\u6562\u505a\uff0c\u5c31\u662f\u56e0\u4e3a\u8131\u9776\u7684\u4e0d\u786e\u5b9a\u6027\u3001\u5176\u4ed6\u5de8\u5927\u98ce\u9669\u4ee5\u53ca\u66f4\u91cd\u8981\u7684\u4f26\u7406\u3002\u56fd\u5bb6\u4e00\u5b9a\u8981\u8fc5\u901f\u7acb\u6cd5\u4e25\u683c\u76d1\u7ba1\uff0c\u6f58\u591a\u62c9\u9b54\u76d2\u5df2\u7ecf\u6253\u5f00\uff0c\u6211\u4eec\u53ef\u80fd\u8fd8\u6709\u4e00\u7ebf\u673a\u4f1a\u5728\u4e0d\u53ef\u633d\u56de\u524d\uff0c\u5173\u4e0a\u5b83\u3002\u201d<\/p>\n

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\u800c\u8fd9\u6b21\u57fa\u56e0\u7f16\u8f91\u5a74\u513f\uff0c\u5373\u4f7f\u6487\u5f00\u533b\u5b66\u4f26\u7406\u548c\u6280\u672f\u98ce\u9669\uff08\u4e3b\u8981\u662f\u8131\u9776\u98ce\u9669\uff09\u4e0d\u8c08\uff0c\u5355\u5355\u5728\u6280\u672f\u8def\u5f84\u89d2\u5ea6\u4e0a\u4e5f\u6709\u975e\u5e38\u5927\u7684\u7455\u75b5\u3002<\/p>\n

\u7f8e\u56fd\u6ce2\u58eb\u987fBIDMC\u533b\u5b66\u4e2d\u5fc3\u535a\u58eb\u540e\u738b\u5b87\u6b4c\u5728\u5fae\u535a\u4e0a\u8868\u793a\uff0c\u6709\u6587\u7ae0\u8bc1\u660e\uff0c\u4e2d\u56fd\u827e\u6ecb\u75c5\u75c5\u6bd2\u4e3b\u8981\u6d41\u884c\u7684\u662fAE\u4e9a\u578b\uff0c\u5360\u6bd4\u4e3a46%\uff0c\u540c\u65f6\u53d1\u73b0\u8be5\u6bd2\u682aX4\u55dc\u6027\uff0c\u8be5\u6bd2\u682a\u6bd2\u682a\u6210\u4e86\u4e2d\u56fd\u6d41\u884c\u6bd2\u682a\u3002\u8fd9\u4e2a\u6bd2\u682a\u6210\u4e86\u4e2d\u56fd\u6d41\u884c\u682a\u7684\u59cb\u7956\u75c5\u6bd2\uff08founder virus\uff09\uff0c\u8fd9\u4e2a\u75c5\u6bd2\u662fR4\u55dc\u9178\u6027\uff0c\u5982\u679c\u8981\u7f16\u8f91\u57fa\u56e0\u5e94\u8be5\u7f16\u8f91CXCR4\u3002\u4f46\u6572\u9664CXCR4\u4f1a\u5f71\u54cd\u80da\u80ce\u53d1\u80b2\uff0c\u6240\u4ee5\u4e0d\u80fd\u6572\u9664CXCR4\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u2014\u2014\u901a\u4fd7\u7684\u8bb2\uff0c\u4e9a\u6d32\u6d41\u884c\u7684\u662fCXCR4\u4e9a\u578b\uff0c\u4e0d\u662fCCRS5\uff0c\u8d3a\u6559\u6388\u6572\u9519\u4e86\u3002\u6df1\u5733\u5b54\u96c0\u4eba\u624d\u7684\u8fd9\u4e2a\u5b9e\u9a8c\uff0c\u77ac\u95f4\u4ece\u4f26\u7406\u95ee\u9898\uff0c\u53d8\u6210\u4e86\u80fd\u529b\u95ee\u9898\u3002<\/p>\n

\u6df1\u5733\u5b54\u96c0\u8ba1\u5212\u63a8\u51fa\u77ed\u77ed10\u5e74\u4e0d\u5230\u65f6\u95f4\uff0c\u5355\u5355\u6df1\u5733\u5357\u65b9\u79d1\u6280\u5927\u5b66\u5df2\u7ecf\u62e5\u6709\u8fd1\u767e\u540d\u7684\u5b54\u96c0\u8ba1\u5212\u4eba\u624d\uff08http:\/\/www.sustc.edu.cn\/faculty_21\uff09\u3002\u7b14\u8005\u9ad8\u5ea6\u8d5e\u540c\u5bf9\u4f18\u79c0\u4eba\u624d\u7684\u5f15\u5165\u653f\u7b56\uff0c\u4f46\u662f\u8fd9\u91cc\u6709\u591a\u5c11\u4eba\u624d\u914d\u5176\u4f4d\uff0c\u53c8\u6709\u591a\u5c11\u4eba\u56e0\u4e3a\u8fd9\u4e9b\u653f\u7b56\u7740\u6025\u4e8e\u505a\u51fa\u6210\u679c\uff0c\u6700\u540e\u94e4\u800c\u8d70\u9669\uff1f\u6df1\u5733\u65b9\u9762\u662f\u5426\u5177\u5907\u76f8\u5e94\u7684\u7504\u9009\u53ca\u52a9\u4f18\u80fd\u529b\uff1f<\/p>\n

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\u7b2c\u4e09\uff0c\u7531\u4e8e\u672a\u91c7\u8bbf\u9664\u4e86\u8d3a\u5efa\u594e\u4ee5\u5916\u7684\u76f4\u63a5\u5f53\u4e8b\u65b9\uff0c\u6587\u7ae0\u4e3a\u4e86\u589e\u52a0\u7f6e\u4fe1\u5ea6\uff0c\u5f15\u7528\u4e86\u7f8e\u56fd\u54c8\u4f5b\u533b\u5b66\u9662\u9057\u4f20\u5b66\u6559\u6388\u3001\u57fa\u56e0\u5de5\u7a0b\u77e5\u540d\u4e13\u5bb6\u4e54\u6cbb\u4e18\u5947\uff08George Church\uff09\u7684\u89c2\u70b9\uff1a\u201c\u8003\u8651\u5230HIV \u5bf9\u5168\u7403\u516c\u5171\u5065\u5eb7\u7684\u5a01\u80c1\u6709\u6269\u5927\u7684\u8d8b\u52bf\uff0c\u6211\u8ba4\u4e3a\u8d3a\u5efa\u594e\u9009\u62e9\u4e86\u4e00\u4e2a\u975e\u5e38\u597d\u7684\u76ee\u6807\u57fa\u56e0\u3002\u201d<\/p>\n

\u4f46\u662f\u6b64\u5904\u7684\u82f1\u6587\u539f\u6587\u62a5\u9053\u5b8c\u5168\u662f\u5728\u53cd\u5bf9\u8fd9\u9879\u5b9e\u9a8c\uff0c\u90a3\u53e5\u8bdd\u4ec5\u4ec5\u4e3a\u4e00\u53e5\u5ba2\u5957\u8bdd\uff0c\u4e54\u6cbb\u4e18\u5947\u8ba4\u4e3a\u8fd9\u9879\u5b9e\u9a8c\u4f1a\u589e\u52a0\u5b69\u5b50\u7684\u65e0\u6570\u672a\u77e5\u98ce\u9669\uff0c\u5c24\u5176\u201cmain emphasis was on testing editing rather than avoiding this disease\u201d\u8fd9\u53e5\u66f4\u662f\u76f4\u6307\u8d3a\u5efa\u594e\u7684\u7814\u7a76\u76ee\u6807\u5e76\u975e\u62b5\u6297\u827e\u6ecb\u75c5\u3002\u2014\u2014\u4eba\u6c11\u7f51\u6587\u7ae0\u628a\u8fd9\u4e9b\u4e0d\u5229\u89c2\u70b9\u5168\u90e8\u5ffd\u7565\u3002<\/p>\n

\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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2017\u5e7412\u6708\uff0c\u56e0\u5408\u751f\u7269\u83b7\u5f97\u6fb3\u94f6\u8d44\u672c\u9886\u59342000\u4e07pre-A\u8f6e\u878d\u8d44\uff0c\u6fb3\u94f6\u8d44\u672c\u540c\u6837\u662f\u4e00\u5bb6BASE\u5728\u6df1\u5733\u7684\u80a1\u6743\u6295\u8d44\u673a\u6784\u3002\u800c\u6210\u7acb\u65f6\u95f4\u6700\u65e9\u7684\u701a\u6d77\u57fa\u56e0\uff0c\u5df2\u57282018\u5e744\u6708\u5b8c\u62102.18\u4ebf\u5143\u4eba\u6c11\u5e01\u7684A\u8f6e\u878d\u8d44\uff0c\u7531\u540c\u665f\u8d44\u672c\u9886\u6295\uff0c\u5e0c\u5937\u8d44\u4ea7\u7b49\u4e94\u5bb6\u673a\u6784\uff08\u5176\u4e2d\u4e24\u5bb6\u6765\u81ea\u6df1\u5733\uff09\u53c2\u4e0e\u8ddf\u6295\u3002<\/p>\n

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\u53e6\u4e00\u65b9\u9762\uff0c\u5404\u79cd\u98ce\u6295\u57fa\u91d1\u4e5f\u5e0c\u671b\u81ea\u5df1\u80fd\u62bc\u4e2d\u4e0b\u4e00\u4e2a\u72ec\u89d2\u517d\u30022014\u5e74\u8d77\uff0c\u7f8e\u4e2d\u4e24\u56fd\u7eb7\u7eb7\u52a0\u5927\u5bf9CRISPR\/Cas9\u6280\u672f\u7684\u79d1\u7814\u6295\u5165\uff0c\u4ee5\u5728\u7f8e\u4e0a\u5e02\u7684\u76f4\u63a5\u4ee5CRISPR\u7597\u6cd5\u547d\u540d\u7684CRISPR Therapeutics\uff08CRSP\uff09\u516c\u53f8\u4e3a\u4f8b\uff0c\u81ea\u5ba3\u5e03\u5373\u5c06\u5c55\u5f00\u9996\u6b21\u4e34\u5e8a\u6d4b\u9a8c\u540e\uff0c\u80a1\u4ef7\u5927\u6da8\u3002\u8fd9\u91cc\u57fa\u91d1\u7f16\u8f91\u6280\u672f\u786e\u5b9e\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u98ce\u53e3\u3002<\/p>\n

\"\"<\/a><\/p>\n

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\u4e8c\u3001Novartis\u548cKarolinksa Institute\u53cc\u53cc\u5728Nature Medicine\uff08\u81ea\u7136\uff09\u671f\u520a\u53d1\u8868\u8bba\u6587\uff0c\u6307\u51faCRISPR\u7f16\u8f91\u57fa\u56e0\u65f6\uff0c\u7ec6\u80de\u53d1\u73b0DNA\u51fa\u73b0\u53d8\u5316\uff0c\u4f1a\u5206\u6cccp53\u86cb\u767d\u8d28\u4fee\u8865\u57fa\u56e0\uff0c\u65e0\u6cd5\u4fee\u590d\u65f6\u5c31\u541e\u566c\u6d88\u706d\u7ec6\u80de\u3002CRISPR\u53ef\u80fd\u4f1a\u5f71\u54cdp53\u529f\u80fd\uff0c\u4ece\u800c\u5bb9\u6613\u5f15\u53d1\u764c\u75c7\u3002\u8be5\u7814\u7a76\u6709\u7406\u6709\u636e\uff0c\u5c31\u8fdeCRISPR Therapeutics\u9996\u5e2d\u6267\u884c\u5b98Samarth Kulkarni\u90fd\u8bf4\u62a5\u544a\u770b\u8d77\u6765\u53ef\u4fe1\u3002\u56e0\u6b64\uff0cCRISPR Therapeutics\u80a1\u4ef7\u5df2\u7ecf\u4ece\u4eca\u5e74\u4e94\u6708\u4efd\u9ad8\u70b973.9\u7f8e\u5143\u7206\u8dcc\u81f3\u8fd1\u671f\u768435.66\u7f8e\u5143\u3002\uff08\u6458\u81ea\u5fae\u535a\u201c\u767d\u8863\u5c71\u732b\u201d \uff09<\/p>\n

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\"\"<\/a><\/p>\n

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2018\u5e7411\u670826\u65e5\u4e0b\u5348\uff0c\u6b64\u65f6\u57fa\u56e0\u7f16\u8f91\u5a74\u513f\u7684\u65b0\u95fb\u5df2\u7ecf\u95f9\u5f97\u6ee1\u57ce\u98ce\u96e8\uff0c\u4f46\u662f\u6df1\u5733\u5357\u65b9\u79d1\u6280\u5927\u5b66\u65b9\u9762\u5f02\u5e38\u5730\u5b89\u9759\u3002<\/p>\n

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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2017\u5e745\u67081\u65e5\uff0c\u7f57\u6e56\u533a\u4eba\u6c11\u533b\u9662\u5987\u4ea7\u79d1\u4e0e\u751f\u6b96\u533b\u5b66\u79d1\u4e3b\u4efb\u5f20\u5e1d\u5f00\u7b7e\u5b57\u540c\u610f\u5f00\u5c55\u8fd9\u4e00\u7814\u7a76\u30022017\u5e746\u67082\u65e5\uff0c\u8be5\u533b\u9662\u533b\u5b66\u4f26\u7406\u59d4\u5458\u4f1a\u4e3b\u4efb\u59d4\u5458\u5f20\u79c0\u660e\u7b7e\u5b57\uff0c\u5e76\u76d6\u7ae0\u201c\u7ecf\u533b\u9662\u4f26\u7406\u59d4\u5458\u4f1a\u5ba1\u6838\u65e0\u8fdd\u53cd\u4f26\u7406\u3002\u540c\u610f\u5176\u7533\u62a5\u201d\u3002<\/p>\n

\u53e6\u5916\uff0c\u5728\u8d3a\u5efa\u594e\u7814\u7a76\u5ba4\u5b98\u7f51\uff08sustc-genome.org.cn\uff09\u4e0a\uff0c\u6709\u516c\u5f00\u7684\u57fa\u56e0\u7f16\u8f91\u9879\u76ee\u7684\u77e5\u60c5\u540c\u610f\u4e66\u3002\u77e5\u60c5\u540c\u610f\u4e66\u5f00\u5934\u5c31\u76f4\u79f0\uff0c\u8be5\u9879\u76ee\u7ecf\u8d39\u7684\u6765\u6e90\u662f\u5357\u65b9\u79d1\u6280\u5927\u5b66\u3002<\/p>\n

\"\"<\/a><\/p>\n

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\u4e3a\u6b64\uff0c\u5357\u79d1\u5927\u5141\u8bb8\u8d3a\u5efa\u594e\u505c\u85aa\u7559\u804c\uff0c\u5168\u529b\u53d1\u5c55\u81ea\u5df1\u7684\u4e8b\u4e1a\u3002\u201c\u5357\u79d1\u5927\u4e0e\u5176\u4ed6\u9ad8\u6821\u4e0d\u4e00\u6837\u7684\u5730\u65b9\u5728\u4e8e\uff0c\u5b83\u9f13\u52b1\u6559\u6388\u521b\u4e1a\uff0c\u4e3b\u52a8\u7a81\u7834\u673a\u5236\uff0c\u8ba9\u6211\u4eec\u6709\u8db3\u591f\u7684\u7cbe\u529b\u53bb\u521b\u4e1a\u3002\u201d\u8d3a\u5efa\u594e\u8bf4\u3002<\/p>\n

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\"\"<\/a><\/p>\n

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\u800c\u4e14\uff0c2018\u5e742\u6708\u8d3a\u6559\u6388\u505c\u85aa\u7559\u804c\uff0c\u6309\u7167\u6b63\u5e38\u7684\u5de5\u4f5c\u6d41\u7a0b\uff0c\u5fc5\u987b\u8981\u505a\u8ff0\u804c\u548c\u5de5\u4f5c\u4ea4\u63a5\uff0c\u751a\u81f3\u5305\u62ec\u79bb\u804c\u5ba1\u8ba1\uff0c\u8fd9\u91cc\u4f1a\u6709\u591a\u5927\u7684\u7ba1\u7406\u7eb0\u6f0f\uff0c\u624d\u4f1a\u51fa\u73b0\u5bf9\u505c\u85aa\u7559\u804c\u6559\u6388\u7684\u8fdb\u5c55\u6beb\u4e0d\u77e5\u6653\u7684\u60c5\u51b5\uff1f<\/p>\n

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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2015\u5e7412\u670810\u65e5\uff0c\u4e0a\u5e02\u516c\u53f8\u548c\u7f8e\u533b\u7597\u516c\u544a\u79f0\uff0c\u4e0e\u6df1\u5733\u701a\u6d77\u57fa\u56e0\u548c\u9999\u6e2f\u5065\u5eb7\u536b\u89c6\u7b7e\u8ba2\u5408\u4f5c\u6846\u67b6\u534f\u8bae\uff0c\u63a8\u5e7f\u7684\u4e1a\u52a1\u91cc\u9762\u5c31\u5305\u62ec\u8bd5\u7ba1\u5a74\u513f\u548c\u57fa\u56e0\u68c0\u6d4b\u3002\u5728\u8fd9\u6b21\u5408\u4f5c\u534f\u8bae\u7684\u7b7e\u7ea6\u73b0\u573a\uff0c\u4ee3\u8868\u6df1\u5733\u701a\u6d77\u7684\u5c31\u662f\u8d3a\u5efa\u594e\u548c\u6797\u5fd7\u901a\u3002<\/p>\n

\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/p>\n

[1]. \u300a\u72ec\u5bb6\u8c03\u67e5\uff1a\u201c\u57fa\u56e0\u7f16\u8f91\u5a74\u513f\u201d\u7684\u8d3a\u5efa\u594e\u548c\u4ed6\u7684\u795e\u79d8\u5173\u952e\u4eba\u300b\uff0c\u53e9\u53e9\u8d22\u8baf\uff0c2018\u5e74<\/p>\n

[2]. \u300a\u57fa\u56e0\u7f16\u8f91\u5a74\u513f\uff1a\u5185\u5fc3\u6709\u591a\u90aa\u6076\uff0c\u624d\u4f1a\u505a\u6b64\u201c\u79d1\u5b66\u521b\u65b0\u201d\uff1f\u300b\uff0c\u6e2f\u80a1\u90a3\u70b9\u4e8b\uff0c2018\u5e74<\/p>\n

[3]. \u300a\u5168\u7403\u5b66\u8005\u5f3a\u70c8\u8c34\u8d23\u201c\u57fa\u56e0\u7f16\u8f91\u5a74\u513f\u201d \u59cb\u4f5c\u4fd1\u8005\u56de\u5e94\u300b\uff0c\u6bcf\u65e5\u7ecf\u6d4e\u65b0\u95fb\uff0c2018\u5e74<\/p>\n

[4]. \u300a\u8d3a\u5efa\u594e\u7684\u57fa\u56e0\u751f\u610f\uff1a\u6ce8\u518c\u8d44\u672c\u8fc7\u4ebf \u5357\u65b9\u79d1\u5927\u5165\u80a1\u300b\uff0c\u6f8e\u6e43\u65b0\u95fb\uff0c2018\u5e74<\/p>\n

[5]. \u300a\u590d\u76d8\u8d3a\u5efa\u594e\u7684\u4eba\u751f\u8f68\u8ff9\uff1a\u662f\u8c01\u7ed9\u4e86\u4ed6\u52c7\u6c14\u300b\uff0c\u754c\u9762\uff0c2018\u5e74<\/p>\n

[6]. \u300a\u6559\u80b2\u90e8\u201c\u4e03\u9879\u89c4\u5b9a\u201d\u51fa\u53f0 \u9ad8\u6821\u9886\u5bfc\u5e72\u90e8\u4e0d\u5f97\u968f\u610f\u517c\u804c\u300b\uff0c\u4eba\u6c11\u7f51\u6559\u80b2\u9891\u9053\uff0c2016\u5e74<\/p>\n

[7]. \u300a\u8d3a\u5efa\u594e\u7684\u57fa\u56e0\u751f\u610f:7\u5bb6\u516c\u53f8\u80a1\u4e1c6\u5bb6\u516c\u53f8\u6cd5\u5b9a\u4ee3\u8868\u4eba\u300b\uff0c\u65b0\u4eac\u62a5\uff0c2018\u5e74<\/p>\n

[8]. \u300a\u548c\u7f8e\u533b\u7597\u96c6\u56e2\u4e0e\u6cf0\u6e2f\u6df1\u4e09\u4f01\u4e1a\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u300b\uff0c\u9f50\u9c81\u7f51\uff0c2015\u5e74<\/p>\n

[9]. \u300a\u57fa\u56e0\u7f16\u8f91\u5a74\u513f\uff1a\u6cd5\u5f8b\u660e\u786e\u7981\u6b62\uff0c\u5404\u56fd\u5171\u8bc6\u201c\u4e0d\u5f97\u7528\u4e8e\u598a\u5a20\u201d\u300b\uff0c\u6f8e\u6e43\u65b0\u95fb\uff0c2018\u5e74<\/p>\n

\n

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\u5316\u540d”\u8349\u796d”\u7684\u539f\u4e0a\u6d77\u67d0\u5927\u5b66\u7406\u5b66\u6559\u6388\u5728\u63a8\u7279\u4e0a\u6307\u51fa\uff0c\u4e2d\u5171\u79d8\u5bc6\u4e0b\u4ee4\u8fdb\u884c”\u57fa\u56e0\u7f16\u8f91\u5a74\u513f”\u5b9e\u9a8c\uff0c\u5c06\u8fd9\u9879\u4efb\u52a1\u4ea4\u7ed9\u4e2d\u56fd\u5357\u65b9\u79d1\u6280\u5927\u5b66\uff0c\u518d\u7531\u526f\u6559\u6388\u8d3a\u5efa\u594e\u4ed8\u8bf8\u5b9e\u8df5\uff0c\u4ece4\u4e2a\u8ff9\u8c61\u4e0d\u96be\u770b\u51fa\u4e2d\u56fd\u653f\u5e9c\u5c31\u662f\u5e55\u540e\u64cd\u76d8\u624b\uff0c\u800c\u4e14\u8d3a\u5efa\u594e\u540d\u4e0b\u67098\u95f4\u751f\u6280\u3001\u79d1\u6280\u516c\u53f8\uff0c\u5747\u6709\u5357\u79d1\u5927\u7684\u6295\u8d44\u6848\u5728\u5176\u4e2d\u3002<\/p>\n

“\u8349\u796d”\u6df1\u5165\u89e3\u91ca\uff0c\u8be5\u5b9e\u9a8c\u52a8\u8f84\u7834\u4ebf\u5143\u7684\u7814\u7a76\u7ecf\u8d39\uff0c\u5e76\u975e\u533a\u533a\u4e00\u4e2a\u526f\u6559\u6388\u80fd\u72ec\u529b\u4e89\u53d6\uff0c\u4e00\u5b9a\u6709\u4e2d\u56fd\u79d1\u6280\u90e8\u6491\u8170\uff1b\u8d3a\u5efa\u594e\u662f\u4e2d\u5171\u900f\u8fc7”\u5343\u4eba\u8ba1\u5212”\u4ece\u6d77\u5916\u5f15\u8fdb\u7684\u4eba\u624d\uff0c\u5728\u5357\u65b9\u79d1\u6280\u5927\u5b66\u7559\u804c\u505c\u85aa\u505a\u7814\u7a76\uff0c\u4e5f\u7edd\u5bf9\u6709\u7ecf\u8fc7\u5b98\u65b9\u8bb8\u53ef\uff1b\u4e2d\u56fd\u79d1\u6280\u90e8\u4e5f\u6709”\u4e13\u9879\u7ecf\u8d39”\u63d0\u4f9b\u7ed9\u8fd9\u79cd\u89c1\u4e0d\u5f97\u5149\u7684\u7814\u7a76\uff1b\u8be5\u5b9e\u9a8c\u6d89\u53ca\u8bb8\u591a\u5e73\u6c11\u53c2\u4e0e\uff0c”\u6ca1\u6709\u56fd\u5bb6\u529b\u91cf\u529e\u4e0d\u5230”\u3002<\/p>\n

“\u8349\u796d”\u63d0\u5230\uff0c\u8d3a\u5efa\u9035\u5e76\u975e\u533b\u5e08\uff0c\u672c\u5e94\u8be5\u65e0\u6cd5\u4ece\u4e8b”\u57fa\u56e0\u7f16\u8f91\u5a74\u513f”\u4eba\u4f53\u5b9e\u9a8c\uff0c\u82e5\u4ed6\u53ea\u662f\u5355\u7eaf\u81ea\u884c\u7b79\u63aa\u7ecf\u8d39\u8fdb\u884c\u7814\u7a76\uff0c\u5357\u79d1\u5927\u5c31\u8be5\u89e3\u8058\u4ed6\uff0c\u4e5f\u4f1a\u88ab\u4e2d\u5171\u4ee5\u53f8\u6cd5\u5236\u88c1\uff0c\u751a\u81f3\u4ed8\u51fa\u949c\u989d\u8d54\u507f\uff0c\u4ece\u4e8b\u4ef6\u53d1\u5c55\u6001\u52bf\u6765\u770b\uff0c\u5b8c\u5168\u6ca1\u6709\u4e0a\u8ff0\u8ff9\u8c61\uff0c”\u8fd9\u8bf4\u660e\u80cc\u540e\u662f\u653f\u5e9c\u5728\u6491\u8170”\uff0c\u4f46\u73b0\u5728\u8d3a\u5efa\u9035\u6700\u5927\u7684\u95ee\u9898\u662f”\u4e0d\u5c0f\u5fc3\u6cc4\u9732\u4e86\u56fd\u5bb6\u673a\u5bc6”\uff0c\u5df2\u7ecf\u53d8\u6210\u4ed6”\u6700\u5927\u7684\u9ebb\u70e6”\u3002<\/p>\n

\n

\u5b98\u65b9\u7591\u653e\u5f03\u529b\u633a\u57fa\u56e0\u7f16\u8f91 “\u6c11\u65cf\u9a84\u50b2”\u9677\u8fc7\u8857\u8001\u9f20<\/strong><\/p>\n

\u6765\u6e90\uff1a\u500d\u53ef\u4eb2<\/p>\n

\u6709\u5173\u4e2d\u56fd\u7814\u7a76\u4eba\u5458\u8868\u793a\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u4f7f\u5a74\u513f\u8bde\u751f\u4e00\u4e8b\uff0c\u65e5\u672c\u533b\u5e08\u4f1a\u4e0e\u65e5\u672c\u533b\u5b66\u4f1a30\u65e5\u53d1\u8868\u58f0\u660e\u4e25\u5389\u8c34\u8d23\u79f0\uff1a\u201c\u8fd9\u662f\u65e0\u89c6\u4eba\u7684\u5c0a\u4e25\uff0c\u8f7b\u89c6\u751f\u547d\uff0c\u4ece\u56fd\u9645\u6027\u4f26\u7406\u89c4\u8303\u6765\u770b\u4e5f\u8131\u79bb\u5e38\u8f68\u3002\u201d\u745e\u58eb\u533b\u5b66\u754c\u4e5f\u8c34\u8d23\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u4f7f\u5a74\u513f\u8bde\u751f\u4e8b\u4ef6\u3002\u4e2d\u56fd\u5b98\u65b9\u5a92\u4f53\u53d1\u8868\u6279\u8bc4\uff0c\u8c34\u8d23\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u8bde\u751f\u5a74\u513f\u3002\u4e16\u754c\u5404\u56fd\u90fd\u5728\u7814\u7a76\u57fa\u56e0\u6539\u53d8\u6280\u672f\uff0c\u4f46\u7edd\u5bf9\u7981\u6b62\u5c06\u80da\u80ce\u79fb\u690d\u4eba\u7c7b\u5b50\u5bab\u662f\u9053\u5fb7\u5e95\u7ebf\u3002\u4e2d\u56fd\u662f\u9996\u4f8b\u3002<\/p>\n

\u636e\u6cd5\u65b0\u793e\u4eca\u5929\u53d1\u81ea\u5317\u4eac\u62a5\u9053\uff0c\u4e2d\u56fd\u4e00\u5bb6\u79f0\u662f\u975e\u653f\u5e9c\u7ec4\u7ec7\u97f3\u8bd1\u4e3a\u767d\u6866\u6797\u8d1f\u8d23\u4eba\u4eca\u5929\u8868\u793a\u5bf9\u652f\u6301\u4e86\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u4f7f\u5a74\u513f\u8bde\u751f\u7684\u79d1\u7814\u4e0e\u843d\u5b9e\u8ba1\u5212\u9057\u61be\u3002 \u8be5\u767d\u6866\u6797\u7ec4\u7ec7\u5411\u4e2d\u56fd\u751f\u7269\u79d1\u5b66\u5bb6\u8d3a\u5efa\u594e\u9001\u4ea4\u4e8650\u4e2a\u5bb6\u5ead\u4f5c\u4e3a\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u4f7f\u5a74\u513f\u8bde\u751f\u7684\u9009\u62e9\u6837\u672c\u3002<\/p>\n

\u8be5\u7ec4\u7ec7\u8d1f\u8d23\u4eba\u8bf4\u4ed6\u88ab\u6b3a\u9a97\u4e86\uff0c\u4f46\u4ed6\u53c8\u8bf4\u4e0d\u4f1a\u63a8\u5378\u81ea\u5df1\u7684\u8d23\u4efb\u3002<\/p>\n

\u8be5\u975e\u653f\u5e9c\u7ec4\u7ec7\u901a\u8fc7\u7f51\u7edc\u4e0e\u4e0d\u540c\u7fa4\u4f53\u8054\u7edc\u6c9f\u901a\uff0c\u5e76\u4e0e\u8d3a\u5efa\u594e\u4fdd\u6709\u8054\u7cfb\u3002<\/p>\n

\u4e2d\u56fd\u8bde\u751f\u4e16\u754c\u9996\u4f8b\u57fa\u56e0\u7f16\u8f91\u5a74\u513f\u5728\u56fd\u9645\u95f4\u5f15\u53d1\u666e\u904d\u6279\u8bc4\u3002\u636e\u745e\u58eb\u65b0\u95fb\u7a0d\u65e9\u62a5\u9053\uff0c\u5c31\u672c\u5468\u4e00(11\u670826\u65e5)\uff0c\u6765\u81ea\u4e2d\u56fd\u6df1\u5733\u7684\u751f\u7269\u79d1\u5b66\u5bb6\u8d3a\u5efa\u594e\u5ba3\u79f0\uff0c\u4ed6\u4f7f\u7528CRISPR\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u4fee\u6539\u4e86\u4e00\u5bf9\u53cc\u80de\u80ce\u7684\u80da\u80ce\u57fa\u56e0\uff0c\u4f7f\u5176\u5bf9\u827e\u6ecb\u75c5\u5177\u6709\u62b5\u6297\u529b\uff0c\u8fd9\u5bf9\u5a74\u513f\u5df2\u4e8e\u51e0\u5468\u524d\u5728\u4e2d\u56fd\u8bde\u751f\u3002\u8fd9\u4e2a\u4e16\u754c\u9996\u4f8b\u57fa\u56e0\u7f16\u8f91\u5a74\u513f\u7684\u6d88\u606f\u9707\u60ca\u4e86\u6574\u4e2a\u79d1\u5b66\u754c\u3002<\/p>\n

\u745e\u58eb\u516c\u5171\u7535\u89c6\u53f0SRF\u5c31\u6b64\u91c7\u8bbf(\u5fb7)\u5916\u90e8\u94fe\u63a5\u4e86\u5f17\u91cc\u5821\u5927\u5b66\u793e\u4f1a\u4f26\u7406\u5b66\u6559\u6388\u3001\u745e\u58eb\u56fd\u5bb6\u4f26\u7406\u59d4\u5458\u4f1a\u4eba\u7c7b\u533b\u5b66\u9886\u57df\u526f\u4e3b\u5e2d\u9a6c\u5e93\u65af\u00b7\u9f50\u9ed8\u66fc(Markus Zimmermann)\u3002\u4ed6\u8868\u793a\uff0c\u6b64\u4e3e\u662f\u201c\u771f\u6b63\u7684\u75af\u72c2\u201d\uff0c\u867d\u7136\u4ed6\u5bf9\u8d3a\u5efa\u594e\u5728\u5176\u89c6\u9891\u5ba3\u8a00(\u82f1)\u5916\u90e8\u94fe\u63a5\u4e2d\u6240\u8a00\u611f\u5230\u540c\u60c5\uff0c\u4f46\u8ba4\u4e3a\u5176\u505a\u6cd5\u5728\u9053\u5fb7\u4e0a\u6beb\u65e0\u9053\u7406\u53ef\u8a00\uff0c\u800c\u4e14\u201c\u4ee4\u4eba\u96be\u4ee5\u7f6e\u4fe1\u7684\u662f\uff0c\u4ed6\u8f7b\u677e\u5730\u63a8\u7ffb\u4e86\u5168\u7403\u60ef\u4f8b\u201d\u3002<\/p>\n

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\u4ed6\u8ba4\u4e3a\uff0c\u5373\u4f7f\u75be\u75c5\u53ef\u4ee5\u56e0\u6b64\u6cbb\u6108\uff0c\u4ecd\u9700\u8981\u8c28\u614e\u8003\u8651\uff0c\u56e0\u4e3a\u8fd9\u662f\u201c\u5bf9\u5177\u6709\u5168\u7403\u91cd\u8981\u6027\u7684\u4eba\u7c7b\u57fa\u56e0\u7ec4\u7684\u5927\u89c4\u6a21\u5165\u4fb5\u201d\uff0c\u8fd9\u5bf9\u53cc\u80de\u80ce\u5973\u5a74\u4e5f\u4f1a\u5c06\u8fd9\u79cd\u7279\u5b9a\u7684\u57fa\u56e0\u6539\u53d8\u4f20\u9012\u7ed9\u5979\u4eec\u7684\u540e\u4ee3\u3002<\/p>\n

\u636e\u62a5\u9053\uff0c\u8d3a\u5efa\u594e\u56e2\u961f\u91c7\u7528\u7684\u662fCrispr\/Cas9\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u3002\u82cf\u9ece\u4e16\u5927\u5b66\u7684\u9a6c\u4e01\u00b7\u5409\u5185\u514b(Martin Jinek)\u7684\u7814\u7a76\u5bf9Crispr \/Cas9\u6d41\u7a0b\u7684\u53d1\u5c55\u4f5c\u51fa\u4e86\u663e\u8457\u8d21\u732e\uff0c\u4ed6\u5411\u745e\u58eb\u901a\u8baf\u793e(Keystone-SDA)\u8868\u793a\uff0c\u7814\u7a76\u754c\u5bf9\u4eba\u7c7b\u80da\u80ce\u7684\u57fa\u56e0\u7578\u53d8\u6709\u7740\u6df1\u8fdc\u7684\u5171\u8bc6 — \u867d\u7136Crispr\/Cas9\u662f\u4e00\u9879\u5c16\u7aef\u6280\u672f\uff0c\u4f46\u8fd8\u5b58\u5728\u5bf9\u5b89\u5168\u6027\u548c\u957f\u671f\u5f71\u54cd\u7684\u62c5\u5fe7\uff0c\u8d3a\u5efa\u594e\u7684\u505a\u6cd5\u7b49\u540c\u4e8e\u8fdb\u884c\u4eba\u7c7b\u5b9e\u9a8c\u3002<\/p>\n

\u82cf\u9ece\u4e16\u5927\u5b66\u751f\u7269\u533b\u5b66\u4f26\u7406\u4e0e\u533b\u5b66\u53f2\u7814\u7a76\u6240\u6240\u957f\u5c3c\u53e4\u62c9\u00b7\u6bd4\u52d2-\u5b89\u591a\u8bfa(Nikola Biller-Andorno)\u6307\u51fa\uff0c\u5df2\u7ecf\u6709\u4e00\u4e9b\u66ff\u4ee3\u65b9\u6848\u53ef\u4ee5\u4fdd\u62a4\u513f\u7ae5\u514d\u53d7\u827e\u6ecb\u75c5\u6bd2\u611f\u67d3\uff0c\u800c\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u662f\u4e00\u9879\u9ad8\u98ce\u9669\u7684\u5b9e\u9a8c\uff0c\u5bf9\u4e8e\u8fd9\u4e9b\u5b69\u5b50\u6765\u8bf4\uff0c\u6240\u5e26\u6765\u7684\u76ca\u5904\u5e76\u201c\u4e0d\u53ef\u9760\u201d\u3002 \u4ed6\u8ba4\u4e3a\uff0c \u8d3a\u5efa\u594e\u7684\u8fd9\u4e00\u505a\u6cd5\u5df2\u7ecf\u201c\u4e0e\u9057\u4f20\u6027\u75be\u75c5\u7684\u6cbb\u7597\u65e0\u5173\uff0c\u800c\u662f\u5f88\u660e\u786e\u5730\u4e0e\u4f18\u5316\u6709\u5173\u201d\u3002<\/p>\n

\u62a5\u9053\u8bf4\uff0c\u5927\u591a\u6570\u79d1\u5b66\u5bb6\u5bf9\u57fa\u56e0\u7f16\u8f91\u4ecd\u7136\u4fdd\u6301\u5c0f\u5fc3\u8c28\u614e\u6001\u5ea6\uff0c\u6bd4\u52d2-\u5b89\u591a\u8bfa\u611f\u5230\u60ca\u8bb6\u7684\u662f\uff0c\u8d3a\u5efa\u594e\u56e2\u961f\u8fdb\u884c\u80da\u80ce\u57fa\u56e0\u6539\u9020\u7684\u51b3\u7b56\u8fc7\u7a0b\u5982\u6b64\u8fc5\u901f\u3002\u76ee\u524d\uff0c\u79d1\u5b66\u754c\u4e3a\u4e86\u8fdb\u4e00\u6b65\u4e86\u89e3\u5176\u98ce\u9669\uff0c\u5df2\u7ecf\u81ea\u884c\u6682\u505c\u76f8\u5173\u7814\u7a76\u3002\u4ed6\u8bf4\uff0c\u73b0\u5728\u901a\u8fc7\u80da\u80ce\u690d\u5165\u524d\u8bca\u65ad\uff0c\u9ad8\u98ce\u9669\u592b\u5987\u5df2\u7ecf\u6709\u53ef\u80fd\u907f\u514d\u5c06\u4e25\u91cd\u9057\u4f20\u75be\u75c5\u4f20\u64ad\u7ed9\u4e0b\u4e00\u4ee3\uff0c\u6240\u4ee5\u8fd9\u5bf9\u53cc\u80de\u80ce\u7684\u7236\u6bcd\u4ece\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u7684\u5e72\u9884\u63aa\u65bd\u4e0a\u83b7\u76ca\u201c\u975e\u5e38\u5c0f\u201d\u3002<\/p>\n

\u5409\u5185\u514b\u4e0e\u6bd4\u52d2-\u5b89\u591a\u8bfa\u90fd\u4e00\u81f4\u8ba4\u4e3a\uff0c\u8fd9\u6837\u4f7f\u7528\u57fa\u56e0\u7ec4\u7f16\u8f91\u6280\u672f\u662f\u4e00\u79cd\u4e0d\u8d1f\u8d23\u4efb\u7684\u505a\u6cd5\u3002<\/p>\n

\u636e\u5171\u540c\u793e\u4eca\u5929\u62a5\u9053\uff0c\u5c31\u4e2d\u56fd\u7814\u7a76\u4eba\u5458\u8868\u793a\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u4f7f\u5a74\u513f\u8bde\u751f\u4e00\u4e8b\uff0c\u65e5\u672c\u533b\u5e08\u4f1a\u4e0e\u65e5\u672c\u533b\u5b66\u4f1a30\u65e5\u53d1\u8868\u58f0\u660e\u4e25\u5389\u8c34\u8d23\u79f0\uff1a\u201c\u8fd9\u662f\u65e0\u89c6\u4eba\u7684\u5c0a\u4e25\uff0c\u8f7b\u89c6\u751f\u547d\uff0c\u4ece\u56fd\u9645\u6027\u4f26\u7406\u89c4\u8303\u6765\u770b\u4e5f\u8131\u79bb\u5e38\u8f68\u3002\u201d<\/p>\n

\u58f0\u660e\u79f0\u5c1a\u4e0d\u6e05\u695a\u57fa\u56e0\u7f16\u8f91\u5a74\u513f\u662f\u5426\u771f\u7684\u8bde\u751f\uff0c\u540c\u65f6\u5f3a\u8c03\u201c\u8be5\u884c\u4e3a\u8df5\u8e0f\u51fa\u751f\u5973\u5a74\u5728\u8eab\u4f53\u3001\u7cbe\u795e\u3001\u793e\u4f1a\u5c42\u9762\u7684\u5b89\u5b81\uff0c\u5f3a\u70c8\u8981\u6c42\u4ece\u4e8b\u7814\u7a76\u53ca\u533b\u7597\u7684\u6240\u6709\u4eba\u4e0d\u8981\u6709\u540c\u6837\u7684\u975e\u4f26\u7406\u884c\u4e3a\u201d\u3002<\/p>\n

\u5bf9\u4e8e\u4e0a\u8ff0\u7814\u7a76\u4eba\u5458\u89e3\u91ca\u79f0\u57fa\u56e0\u7f16\u8f91\u7684\u76ee\u7684\u5728\u4e8e\u9632\u6b62\u827e\u6ecb\u75c5\u6bd2\u4ece\u7236\u4eb2\u4f20\u5230\u5b69\u5b50\uff0c\u58f0\u660e\u6307\u51fa\u201c\u4e5f\u6709\u5176\u4ed6\u9632\u6b62\u4f20\u67d3\u7684\u65b9\u6cd5\uff0c\u5e76\u4e0d\u5b58\u5728\u533b\u5b66\u4e0a\u7684\u5fc5\u8981\u6027\u548c\u59a5\u5f53\u6027\u201d\uff0c\u65ad\u8a00\u5176\u201c\u5f71\u54cd\u4f1a\u6ce2\u53ca\u540e\u4ee3\uff0c\u4e14\u5bf9\u4eba\u7c7b\u8fd9\u4e00\u7269\u79cd\u7684\u5f71\u54cd\u4e5f\u4e0d\u900f\u660e\uff0c\u662f\u6781\u5176\u4e0d\u8d1f\u8d23\u4efb\u7684\u884c\u4e3a\u201d\u3002<\/p>\n

\u636e\u5927`\u7eaa`\u5143\u62a5\u9053\uff0c\u4e2d\u56fd\u5b98\u65b911\u670829\u65e5\u5ba3\u5e03\u6682\u505c\u5357\u65b9\u79d1\u6280\u5927\u5b66\u526f\u6559\u6388\u8d3a\u5efa\u594e\u201c\u57fa\u56e0\u7f16\u8f91\u5a74\u513f\u201d\u7684\u79d1\u7814\u6d3b\u52a8\u3002\u4f46\u6b64\u524d\u8d3a\u5efa\u594e\u7684\u7814\u7a76\u201c\u6210\u679c\u201d\u88ab\u5b98\u5a92\u6b63\u9762\u62a5\u5bfc\uff0c\u5728\u5f15\u53d1\u56fd\u9645\u5f3a\u70c8\u8c34\u8d23\u540e\uff0c\u4e8b\u4ef6\u81f3\u4eca\u4ecd\u5728\u53d1\u9175\u3002<\/p>\n

\u8be5\u62a5\u9053\u8bf4\uff0c\u672c\u4ee5\u4e3a\u83b7\u5f97\u201c\u5de8\u5927\u6210\u529f\u201d\u7684\u8d3a\u5efa\u594e\u88ab\u5b98\u65b9\u201c\u629b\u5f03\u201d\u3002<\/p>\n

\u8fd9\u9879\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u53d1\u660e\u4e8e\u7f8e\u56fd\u800c\u4e14\u5e76\u4e0d\u590d\u6742\uff0c\u56fd\u9645\u79d1\u5b66\u754c\u4e25\u7981\u7528\u4e8e\u4eba\u7c7b\u3002\u5206\u6790\u8ba4\u4e3a\uff0c\u8fd9\u4e00\u5404\u56fd\u65e0\u6cd5\u63a5\u53d7\u7684\u7814\u7a76\u5728\u4e2d\u56fd\u53d1\u751f\uff0c\u663e\u793a\u8d3a\u5efa\u594e\u662f\u5728\u653f\u5e9c\u7684\u652f\u6301\u4e0b\uff0c\u5728\u4e2d\u5171\u5236\u9020\u7684\u65e0\u795e\u8bba\u5927\u73af\u5883\u4e2d\u201c\u65e0\u6cd5\u65e0\u5929\u201d\uff0c\u624d\u6562\u89e6\u78b0\u9053\u5fb7\u4f26\u7406\u5e95\u7ebf\u3002<\/p>\n

\u5468\u56db\uff0829\u65e5\uff09\uff0c\u4e2d\u5171\u5b98\u5a92\u65b0\u534e\u7f51\u62a5\u5bfc\uff0c\u4e2d\u5171\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a\u3001\u79d1\u6280\u90e8\u3001\u4e2d\u56fd\u79d1\u6280\u534f\u4f1a\u7b49\u4e09\u90e8\u95e8\u8d1f\u8d23\u4eba\u8bf4\uff0c\u57fa\u56e0\u7f16\u8f91\u5a74\u513f\u4e8b\u4ef6\u201c\u6027\u8d28\u6781\u5176\u6076\u52a3\uff0c\u5df2\u7ecf\u8981\u6c42\u6709\u5173\u5355\u4f4d\u6682\u505c\u76f8\u5173\u4eba\u5458\u7684\u79d1\u7814\u6d3b\u52a8\uff0c\u5bf9\u8fdd\u6cd5\u8fdd\u89c4\u884c\u4e3a\u575a\u51b3\u4e88\u4ee5\u67e5\u5904\u201d\u3002<\/p>\n

\u4e2d\u5171\u79d1\u6280\u90e8\u526f\u90e8\u957f\u5f90\u5357\u5e73\u5468\u56db\u5728\u63a5\u53d7\u592e\u89c6\u91c7\u8bbf\u65f6\u8868\u793a\uff0c\u57fa\u56e0\u7f16\u8f91\u5a74\u513f\u201c\u516c\u7136\u8fdd\u53cd\u56fd\u5bb6\u76f8\u5173\u6cd5\u89c4\u6761\u4f8b\uff0c\u516c\u7136\u7a81\u7834\u5b66\u672f\u754c\u4f26\u7406\u5e95\u7ebf\uff0c\u4ee4\u4eba\u9707\u60ca\u3002\u201d<\/p>\n

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\u636e\u62a5\u9053\u6307\uff0c\u4f46\u9996\u5148\u62a5\u5bfc\u3001\u5e76\u6b63\u9762\u62a5\u5bfc\u8d3a\u5efa\u594e\u201c\u57fa\u56e0\u7f16\u8f91\u5b9e\u9a8c\u6210\u529f\u201d\u7684\u6d88\u606f\uff0c\u662f\u7531\u4e2d\u5171\u515a\u5a92\u300a\u4eba\u6c11\u65e5\u62a5\u300b\u5468\u4e8c\uff0827\u65e5\uff09\u505a\u51fa\u7684\u3002\u968f\u5373\u79d1\u5b66\u754c\u5185\u5916\u53d1\u751f\u9707\u8361\uff0c\u8d3a\u5efa\u594e\u7684\u7814\u7a76\u53d7\u5230\u5f3a\u70c8\u8c34\u8d23\u3002<\/p>\n

\u6b64\u540e\u4e2d\u5171\u5b98\u65b9\u7684\u6001\u5ea6\u7d27\u6025\u53d1\u751f\u53cd\u8f6c\uff0c\u4e2d\u56fd\u9057\u4f20\u5b66\u4f1a\u3001\u4e2d\u56fd\u79d1\u534f\u751f\u547d\u79d1\u5b66\u5b66\u4f1a\u8054\u5408\u4f53\u4ee5\u53ca\u4e2d\u56fd\u7ec6\u80de\u751f\u7269\u5b66\u5b66\u4f1a\u90fd\u76f8\u7ee7\u53d1\u8868\u58f0\u660e\uff0c\u8c34\u8d23\u5c06\u57fa\u56e0\u4fee\u6539\u7528\u4e8e\u751f\u6b96\u76ee\u7684\u3002<\/p>\n

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