![\"\"](\"http:\/\/blog.jackjia.com\/wp-content\/uploads\/2018\/03\/Charles-Lu.jpg\")
<\/a>\n\uff08LeNano Diagnostics\u516c\u53f8\u9996\u5e2d\u6267\u884c\u5b98Charles Lu\uff09<\/p>\n
\u4ed6\u89e3\u91ca\u8bf4\uff0c\u5b9e\u9a8c\u5ba4\u4e2d\u7684\u6d4b\u8bd5\u9700\u8981\u7531\u4e13\u4e1a\u4eba\u5458\u64cd\u4f5c\u590d\u6742\u7684\u4eea\u5668\uff0c\u4ee5\u76ee\u524d\u7684\u6d4b\u8bd5\u65b9\u6cd5\u9700\u8981\u957f\u8fbe24\u5c0f\u65f6\u7684\u65f6\u95f4\u624d\u80fd\u5f97\u51fa\u7ed3\u679c\uff0c\u6216\u8005\u4ec5\u63d0\u4f9b\u5b9a\u6027\u800c\u4e0d\u5b9a\u91cf\u7684\u975e\u7cbe\u51c6\u7ed3\u8bba\u3002<\/p>\n
\u4ed6\u8bf4\uff0c\u60a3\u6709\u5fc3\u810f\u95ee\u9898\u7684\u60a3\u8005\u901a\u5e38\u9700\u8981\u8fd4\u56de\u533b\u9662\u6216\u53bb\u770b\u533b\u751f\u8fdb\u884c\u68c0\u6d4b\uff0c\u201c\u6211\u4eec\u7684\u5957\u4ef6\u4f7f\u7528\u7b80\u5355\uff0c\u5e76\u5177\u6709\u51c6\u786e\u548c\u5b9a\u91cf\u7684\u7ed3\u679c\uff0c\u60a3\u8005\u80fd\u591f\u4ece\u5bb6\u4e2d\u76d1\u6d4b\u81ea\u5df1\u7684BNP\u6307\u6807\u3002\u201d<\/p>\n
\u800c\u4e14\uff0c\u8be5\u6d4b\u8bd5\u8fd8\u652f\u6301\u84dd\u7259\uff0c\u5141\u8bb8\u5c06\u7ed3\u679c\u81ea\u52a8\u4f20\u8fbe\u7ed9\u8fdc\u7a0b\u533b\u7597\u670d\u52a1\u63d0\u4f9b\u5546\u3002\u4f8b\u5982\uff0c\u5982\u679cBNP\u503c\u63d0\u9ad8\uff0c\u533b\u751f\u53ef\u4ee5\u5efa\u8bae\u75c5\u4eba\u8c03\u6574\u4ed6\u4eec\u7684\u65e5\u5e38\u5de5\u4f5c\u6216\u547c\u53eb\u6551\u62a4\u8f66\u7d27\u6025\u670d\u52a1\u3002\u8be5\u9879\u6280\u672f\u8fd8\u8bbe\u8ba1\u7528\u4e8e\u534f\u52a9\u7d27\u6025\u90e8\u95e8\u6216\u5176\u4ed6\u533b\u7597\u673a\u6784\u4e2d\u4e34\u5e8a\u533b\u751f\u5728\u7d27\u6025\u60c5\u51b5\u4e0b\u80fd\u591f\u4f5c\u51fa\u5feb\u901f\u51c6\u786e\u7684\u8bc4\u4f30\u3002<\/p>\n
\u6ed1\u94c1\u5362\u7814\u53d1\u56e2\u961f\u7684\u8d1f\u8d23\u4ebaYael Zilberman-Simakov\u8868\u793a\uff0c\u201c\u6211\u4eec\u5de5\u4f5c\u7684\u4e3b\u8981\u76ee\u6807\u662f\u5e2e\u52a9\u60a3\u6709\u6162\u6027\u5fc3\u529b\u8870\u7aed\u7684\u4eba\u751f\u6d3b\u5f97\u66f4\u597d\u66f4\u957f\u3002\u201d\u8fd9\u4e00\u7814\u7a76\u83b7\u5f97Mitacs\u8d44\u52a9\u3002<\/p>\n
\u201c\u8fd9\u9879\u7a81\u7834\u6027\u6280\u672f\u7684\u72ec\u7279\u4e4b\u5904\u5728\u4e8e\u5b83\u4f7f\u7528\u4f4e\u6210\u672c\u7684\u7535\u5b50\u4f20\u611f\u5668\u800c\u4e0d\u662f\u9ad8\u6210\u672c\u7684\u5149\u5b66\u4f20\u611f\u5668\uff0c\u201d\u7eb3\u7c73\u6750\u6599\u4e13\u5bb6Zilberman-Simakov\u8bf4\u3002\u5979\u82b1\u4e86\u8fd1\u4e00\u5e74\u534a\u7684\u65f6\u95f4\u5b8c\u5584\u4ea7\u54c1\u539f\u578b\uff0c\u5e76\u4f18\u5316\u7528\u4e8e\u68c0\u6d4b\u8840\u6db2\u4e2dBNP\u7684\u751f\u7269\u533b\u5b66\u5fae\u578b\u4f20\u611f\u5668\u3002<\/p>\n
\u76f8\u5173\u8bd5\u70b9\u9879\u76ee\u5373\u5c06\u5f00\u542f\uff0c\u5979\u8bf4\uff0c\u9884\u8ba1\u8be5\u9879\u6d4b\u8bd5\u7684\u5546\u4e1a\u5e02\u573a\u89c4\u6a21\u5de8\u5927\uff0c\u4ece\u52a0\u62ff\u5927\u8d77\u6b65\uff0c\u53ef\u4ee5\u63a8\u5e7f\u81f3\u7f8e\u56fd\uff0c\u6b27\u6d32\u548c\u4e9a\u6d32\u3002\u5979\u5bf9\u5176\u56e2\u961f\u80fd\u591f\u63d0\u4f9b\u4f4e\u6210\u672c\u6613\u4f7f\u7528\u7684\u6307\u523a\u6d4b\u8bd5\u611f\u5230\u9ad8\u5174\uff0c\u8fd9\u53ef\u4ee5\u5e2e\u52a9\u76ee\u524d\u60a3\u6709\u6162\u6027\u5fc3\u529b\u8870\u7aed\u7684\u7ea660\u4e07\u52a0\u62ff\u5927\u60a3\u8005\uff0c\u4ee5\u53ca\u6bcf\u5e74\u589e\u52a0\u76845\u4e07\u4eba\u3002\u6765\u81ea\u52a0\u62ff\u5927\u5fc3\u529b\u8870\u7aed\u7f51\u7edc\u7684\u7edf\u8ba1\u6570\u636e\u663e\u793a\uff0c\u8fd9\u4e9b\u60a3\u8005\u4e2d\u8fd1\u56db\u5206\u4e4b\u4e00\u53ef\u80fd\u5728\u8bca\u65ad\u540e\u4e00\u5e74\u5185\u91cd\u65b0\u5165\u9662\u3002<\/p>\n
\u201c\u901a\u8fc7\u6211\u4eec\u65b0\u7684\u6d4b\u8bd5\u7cfb\u7edf\uff0c\u6211\u4eec\u53ef\u4ee5\u51cf\u8f7b\u533b\u7597\u7cfb\u7edf\u7684\u4e00\u4e9b\u8d1f\u62c5\uff0c\u540c\u65f6\u4e3a\u60a3\u8005\u63d0\u4f9b\u66f4\u8212\u9002\u7684\u73af\u5883\u6765\u7ba1\u7406\u81ea\u5df1\u7684\u5065\u5eb7\u72b6\u51b5\uff0c\u201d LeNano Diagnostics\u516c\u53f8\u9996\u5e2d\u6267\u884c\u5b98Charles Lu\u8bf4\u3002 \u201c\u8fd9\u662f\u4e00\u79cd\u9ad8\u79d1\u6280\uff0c\u4f4e\u6210\u672c\uff0c\u9ad8\u6548\u76ca\u7684\u533b\u7597\u4fdd\u5065\u89e3\u51b3\u65b9\u6848\u3002\u201d<\/p>\n
Mitacs\uff08\u52a0\u62ff\u5927\u4fe1\u606f\u6280\u672f\u4e0e\u7efc\u5408\u7cfb\u7edf\u6570\u5b66\u7ec4\u7ec7\uff09\u662f\u4e00\u5bb6\u5168\u56fd\u6027\u975e\u725f\u5229\u7814\u7a76\u548c\u57f9\u8bad\u673a\u6784\uff0cMitacs\u7531\u8054\u90a6\u653f\u5e9c\u548c\u7701\u653f\u5e9c\u4ee5\u53ca\u5927\u5b66\u548c\u884c\u4e1a\u5408\u4f5c\u4f19\u4f34\u63d0\u4f9b\u8d44\u91d1\u3002\u901a\u8fc7\u4e0e60\u6240\u5927\u5b66\uff0c\u6570\u5343\u5bb6\u516c\u53f8\u4ee5\u53ca\u8054\u90a6\u653f\u5e9c\u548c\u7701\u653f\u5e9c\u5408\u4f5c\uff0cMitacs\u5efa\u7acb\u4e86\u652f\u6301\u52a0\u62ff\u5927\u5de5\u4e1a\u548c\u793e\u4f1a\u521b\u65b0\u7684\u4f19\u4f34\u5173\u7cfb\u3002\u9879\u76ee\u9762\u5411\u6240\u6709\u5b66\u79d1\u548c\u6240\u6709\u884c\u4e1a\u90e8\u95e8\uff0c\u6d89\u53ca\u5236\u9020\u4e1a\uff0c\u4e1a\u52a1\u6d41\u7a0b\uff0cIT\uff0c\u793e\u4f1a\u79d1\u5b66\uff0c\u8bbe\u8ba1\u7b49\u5e7f\u6cdb\u9886\u57df\u3002<\/p>\n
=============<\/p>\n
\u53c2\u8003\u6587\u732e\uff1a<\/p>\n
\u5168\u9762\u89e3\u8bfb\u5fc3\u5185\u79d1\u5e38\u7528\u6307\u6807\uff1aB \u578b\u5229\u94a0\u80bd<\/strong><\/p>\n 2016-01-30 11:30 \u6765\u6e90\uff1a\u4e01\u9999\u56ed \u4f5c\u8005\uff1a\u56db\u53f6\u866b<\/p>\n \u5229\u94a0\u80bd\uff08NP\uff09\u5bb6\u65cf\u5305\u62ec ANP\u3001BNP\u3001CNP\u3001DNP \u548c VNP \u7b49\uff0c\u662f\u810a\u690e\u52a8\u7269\u4f53\u5185\u7528\u4e8e\u8c03\u8282\u5faa\u73af\u7cfb\u7edf\u7684\u5bb9\u91cf\u548c\u6e17\u900f\u538b\u7684\u4e00\u5927\u7c7b\u7269\u8d28\u3002<\/p>\n \u4ece\u539f\u59cb\u5706\u53e3\u7eb2\u810a\u690e\u52a8\u7269\u5230\u9ad8\u7ea7\u7684\u7075\u957f\u7c7b\u52a8\u7269\u4f53\u5185\u90fd\u53ef\u4ee5\u627e\u5230\u5229\u94a0\u80bd\uff0c\u5176\u4e2d\u6700\u539f\u59cb\u7684\u4e00\u7c7b\u5229\u94a0\u80bd CNP \u53ef\u80fd\u5728\u8fd9\u4e2a\u661f\u7403\u4e0a\u5df2\u7ecf\u5b58\u5728\u4e86\u4e0a\u4ebf\u5e74\uff0c\u8d8a\u9ad8\u7ea7\u7684\u7269\u79cd\u5728\u4f53\u5185\u6240\u80fd\u627e\u5230\u5229\u94a0\u80bd\u5bb6\u65cf\u79cd\u7c7b\u5c31\u8d8a\u591a\u3002\u5f53\u7136\uff0c\u6211\u4eec\u4e34\u5e8a\u533b\u751f\u66f4\u5173\u5fc3\u7684\u662f BNP\u30021988 \u5e74\uff0c\u65e5\u672c\u5b66\u8005 Tetsuji Sudoh \u9996\u6b21\u4ece\u732a\u8111\u5185\u5206\u79bb\u5f97\u5230\u4e00\u79cd\u5177\u6709\u5f3a\u529b\u7684\u5229\u94a0\u3001\u5229\u5c3f\u3001\u6269\u8840\u7ba1\u548c\u964d\u538b\u4f5c\u7528\u7684\u591a\u80bd\uff0c\u56e0\u4e3a\u662f\u4ece\u732a\u8111\u5f53\u4e2d\u5206\u79bb\u7684\uff0c\u6240\u4ee5\u4e73\u540d\u53eb\u8111\u94a0\u80bd\u3002<\/p>\n \u8fd9\u4e2a\u53d1\u73b0\u968f\u5373\u5728\u5927\u540d\u9f0e\u9f0e\u7684 Nature \u6742\u5fd7\u4e0a\u53d1\u8868\u3002\u732a\u4eec\u5f88\u5174\u594b\uff0c\u53ef\u662f\u5b83\u4eec\u5e76\u6ca1\u6709\u9ad8\u5174\u591a\u4e45\uff0c1991 \u5e74 Mukoyama \u7b49\u53d1\u73b0\u5b9e\u9645\u4e0a BNP \u5728\u5f88\u591a\u810f\u5668\u90fd\u53ef\u4ee5\u5206\u6ccc\uff0c\u800c\u4e3b\u8981\u5176\u5b9e\u662f\u7531\u5fc3\u5ba4\u5206\u6ccc\u3002\u968f\u540e 10 \u5e74\u4e2d BNP \u4e00\u76f4\u662f\u751f\u7269\u5b66\u754c\u7814\u7a76\u7684\u70ed\u70b9\u3002\u5176\u540d\u79f0\u7e41\u591a\uff0c\u4e0d\u4f46\u53eb\u8111\u94a0\u80bd\uff0c\u4e5f\u53ef\u4ee5\u53eb\u8111\u94a0\u7d20\u3001\u8111\u5229\u5c3f\u94a0\u80bd\u3001\u8111\u5229\u94a0\u80bd\u3001B \u578b\u94a0\u5229\u5c3f\u80bd\u3001B \u578b\u94a0\u5c3f\u80bd\u3001B \u578b\u4fc3\u5c3f\u94a0\u6392\u6cc4\u80bd\u3001B \u94a0\u5c3f\u80bd\uff0c\u4f46\u6700\u6b63\u89c4\u7684\u547d\u540d\u5e94\u8be5\u662f B \u578b\u5229\u94a0\u80bd\uff08BNP\uff09\u3002<\/p>\n \u770b\u5230\u540c\u4e00\u4e2a\u7269\u8d28\u5728\u6211\u56fd\u80fd\u6709\u8fd9\u4e48\u591a\u5408\u6cd5\u9a6c\u7532\uff0c\u6211\u548c\u6211\u7684\u5c0f\u4f19\u4f34\u4eec\u90fd\u60ca\u5446\u4e86\u3002<\/p>\n BNP \u5b58\u5728\u4e8e\u5fc3\u5ba4\u9694\u819c\u9897\u7c92\u4e2d\uff0c\u5176\u5206\u6ccc\u6709\u8d56\u4e8e\u5fc3\u5ba4\u7684\u5bb9\u79ef\u6269\u5f20\u548c\u538b\u529b\u8d1f\u8377\u589e\u52a0\u3002\u5f53\u5fc3\u808c\u7ec6\u80de\u6536\u5230\u7275\u62c9\u523a\u6fc0\u540e\uff0c\u9996\u5148\u5206\u6ccc pre-proBNP\uff0c\u968f\u540e\u5f62\u6210 proBNP\uff0cproBNP \u5728\u5185\u5207\u9176\u7684\u4f5c\u7528\u4e0b\u88c2\u89e3\u4e3a\u6709\u5229\u94a0\u3001\u5229\u5c3f\u3001\u6269\u8840\u7ba1\u7b49\u751f\u7269\u6d3b\u6027\u7684 BNP \u548c\u65e0\u751f\u7269\u6d3b\u6027\u7684 NT-proBNP\uff08N \u672b\u7aef B \u578b\u5229\u94a0\u80bd\u539f\uff09\u3002<\/p>\n BNP \u4e3b\u8981\u5728\u80ba\u3001\u80be\u810f\u7ecf\u5185\u5207\u9176\u964d\u89e3\u6216\u5927\u8840\u7ba1\u5185\u53d7\u4f53\u6e05\u9664\uff0c\u800c NT-proBNP \u4e3b\u8981\u7ecf\u80be\u810f\u6392\u6cc4\u3002\u56e0\u6b64\u4e34\u5e8a\u4e0a BNP \u53ef\u4ee5\u5236\u6210\u6cbb\u7597\u5fc3\u8870\u7684\u836f\u54c1\uff08\u5982\u65b0\u6d3b\u7d20\uff09\uff0c\u540c\u65f6\u6d4b\u5b9a\u8840\u538b\u4e2d\u7684 BNP \u6216\u8005 NT-proBNP \u6c34\u5e73\u53ef\u4ee5\u5bf9\u5fc3\u8870\u8fdb\u884c\u8bca\u65ad\u548c\u8bc4\u4f30\u3002<\/p>\n \u6b63\u5982\u808c\u9499\u86cb\u767d I \u548c\u808c\u9499\u86cb\u767d T \u90a3\u573a\u65f7\u65e5\u6301\u4e45\u7684\u5927\u4e89\u8bba\u4e00\u6837\uff0c\u4ee5\u535a\u9002\uff08Biosite\uff09\u516c\u53f8\u4e3a\u4ee3\u8868\u7684 BNP \u68c0\u6d4b\u9635\u8425\u548c\u4ee5\u548c\u7f57\u6c0f\uff08Roche\uff09\u516c\u53f8\u4e3a\u4ee3\u8868 NT-proBNP \u68c0\u6d4b\u9635\u8425\u8fd1\u51e0\u5e74\u4e5f\u662f\u64e6\u67aa\u8d70\u706b\uff0c\u662f\u975e\u4e0d\u65ad\u3002\u672c\u6587\u65e0\u610f\u4ecb\u5165\u5546\u573a\u662f\u975e\uff0c\u4f46\u7b80\u5355\u4e86\u89e3\u8fd9\u4e24\u4e2a\u68c0\u6d4b\u65b9\u6cd5\u7684\u5386\u53f2\uff0c\u6709\u52a9\u4e8e\u516c\u6b63\u89e3\u8bfb BNP \u548c NT-proBNP \u7684\u4e34\u5e8a\u610f\u4e49\u3002<\/p>\n 2000 \u5e74 11 \u6708\u7f8e\u56fd Biosite \u516c\u53f8 BNP \u68c0\u6d4b\u65b9\u6cd5\u5f97\u5230\u7f8e\u56fd FDA \u7684\u6279\u51c6\u5e76\u7533\u8bf7\u4e13\u5229\uff0cBiosite \u7684\u4e13\u5229\u4fdd\u62a4\u7684\u5f88\u597d\uff0c\u53ef\u4ee5\u8bf4\u5728 2000 \u5e74\u5230 2005 \u5e74\u4e4b\u95f4\u57fa\u672c\u662f Biosite \u516c\u53f8\u7684 BNP \u72ec\u6b65\u5929\u4e0b\u7684\u65f6\u4ee3\u3002BNP \u7684\u68c0\u6d4b\u610f\u4e49\u5f97\u5230\u51e0\u4e4e\u6240\u6709\u5927\u578b\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09\u7684\u8ba4\u53ef\u3002<\/p>\n \u6700\u65e9\u5728 2001 \u5e74 ESC \u5fc3\u529b\u8870\u7aed\u6307\u5357\uff0c\u7f8e\u56fd 2005 \u5e74 ACC\/AHA \u5fc3\u529b\u8870\u7aed\u6307\u5357\uff0c\u76f4\u81f3\u76ee\u524d\u6b27\u7f8e\u6700\u65b0\u7248\u672c\u5fc3\u8870\u6307\u5357\u90fd\u63a8\u8350\u5c06\u8840\u6db2 BNP \u6c34\u5e73\u6d4b\u5b9a\u4f5c\u4e3a\u5fc3\u529b\u8870\u7aed\u7684\u8bca\u65ad\u548c\u9884\u540e\u6307\u6807\u30022002 \u5e74 11 \u6708\u745e\u58eb Roche \u516c\u53f8 Elecsys NT-proBNP \u5f97\u5230\u7f8e\u56fd FDA \u7684\u6279\u51c6\u5e76\u4e0a\u5e02\u30022005 \u5e74\u4e4b\u540e\u57fa\u4e8e\u4f17\u591a RCT \u7814\u7a76\u7684\u8bc1\u636e\uff0c\u6b27\u7f8e\u5404\u7248\u5fc3\u8870\u6307\u5357\u5f00\u59cb\u63a8\u8350 NT-proBNP \u6c34\u5e73\u6d4b\u5b9a\u4f5c\u4e3a\u5fc3\u529b\u8870\u7aed\u7684\u8bca\u65ad\u548c\u9884\u540e\u6307\u6807\u3002<\/p>\n \u5fc3\u8870\u6807\u5fd7\u7269\u68c0\u6d4b\u5e02\u573a\u662f\u4e00\u5757\u5de8\u5927\u7684\u86cb\u7cd5\uff0c\u6709\u5546\u4e1a\u5229\u76ca\u5c31\u5fc5\u7136\u6709\u7ade\u4e89\uff0c\u6709\u7ade\u4e89\u5c31\u96be\u514d\u76f8\u4e92\u6392\u65a5\u3002\u4f46\u603b\u800c\u8a00\u4e4b\uff0c\u4e24\u8005\u5404\u6709\u5343\u79cb\u3002 \u597d\u7684\uff0c\u505a\u5b8c\u4e86\u4e0a\u9762\u7684\u94fa\u57ab\uff0c\u4e0b\u9762\u624d\u6b63\u5f0f\u5f00\u59cb\u3002<\/p>\n BNP \u548c NT-proBNP \u7684\u6bd4\u8f83<\/p>\n BNP \u548c NT-proBNP \u662f\u7531 proBNP \u7b49\u6469\u5c14\u88c2\u89e3\u800c\u6765\uff0c\u5982\u4e0a\u8868\u6240\u793a\u4e8c\u8005\u6709\u5f88\u591a\u4e0d\u540c\u70b9\u3002\u4e0d\u540c\u89d2\u5ea6\u5c31\u6709\u4e0d\u540c\u7684\u89e3\u8bfb\uff0c\u4f18\u70b9\u6709\u65f6\u4ece\u53e6\u4e00\u89d2\u5ea6\u770b\u53ef\u4ee5\u53d8\u6210\u7f3a\u70b9\u3002<\/p>\n \u66f4\u957f\u7684\u534a\u8870\u671f\u4f3c\u4e4e\u610f\u5473\u7740\u66f4\u957f\u7684\u68c0\u6d4b\u7a97\u53e3\uff0c\u4e0d\u6613\u6f0f\u8bca\u5fc3\u8870\uff0c\u4f46\u5374\u4e0d\u80fd\u5373\u65f6\u5feb\u901f\u5224\u5b9a\u5fc3\u8870\u7684\u6cbb\u7597\u6548\u679c\u548c\u76ee\u524d\u771f\u5b9e\u7684\u5fc3\u8870\u75c5\u60c5\uff0c\u8fd9\u4e8c\u8005\u5728\u5fc3\u8870\u8bca\u65ad\u8bca\u7597\u4e2d\u54ea\u4e00\u4e2a\u66f4\u91cd\u8981\u663e\u800c\u6613\u89c1\u3002\u800c\u5c31\u76ee\u524d\u514d\u75ab\u68c0\u6d4b\u6c34\u5e73\uff0c\u4e8c\u8005\u8840\u6db2\u6d53\u5ea6\u5dee\u522b\u65e9\u5df2\u4e0d\u662f\u95ee\u9898\u3002\u542b\u6297\u51dd\u5242\u7684\u975e\u7845\u5316\u73bb\u7483\u8bd5\u7ba1\u4e5f\u4e0d\u4f1a\u589e\u52a0\u5f88\u591a\u68c0\u9a8c\u6210\u672c\u3002\u5e38\u6e29\u534a\u5929\u7a33\u5b9a\u5b58\u653e\u5df2\u8db3\u591f\u6ee1\u8db3\u4e34\u5e8a\u68c0\u9a8c\u8981\u6c42\uff0c\u4f3c\u4e4e\u770b\u4e0d\u51fa\u7a33\u5b9a\u4fdd\u5b58 1 \u5468\u6709\u4ec0\u4e48\u4e34\u5e8a\u4ef7\u503c\uff0c\u6211\u4eec\u4e5f\u4e0d\u53ef\u80fd\u7b49\u4e0a\u4e00\u5468\u518d\u770b\u68c0\u67e5\u7ed3\u679c\u3002<\/p>\n \u5728 BNP \u548c NT-proBNP \u4f17\u591a\u4e0d\u540c\u70b9\u4e2d\u53ea\u6709\u53d7\u80be\u529f\u80fd\u5f71\u54cd\u662f\u65e0\u6cd5\u89e3\u51b3\u7684\uff0c\u8fd9\u4e00\u70b9\u5728\u4e0b\u6587\u4f1a\u8be6\u7ec6\u63d0\u53ca\u3002\u5f53\u7136\u65e0\u8bba\u662f BNP \u8fd8\u662f NT-proBNP \u5728\u5fc3\u8870\u4e2d\u5e94\u7528\u90fd\u662f\u5bf9\u4e34\u5e8a\u4e86\u4e0d\u8d77\u7684\u8d21\u732e\u3002<\/p>\n BNP \/ NT-proBNP \u4e0e\u6025\u6027\u5fc3\u8870<\/p>\n BNP \/ NT-proBNP \u6307\u6807\u5728\u5fc3\u8870\u8bca\u65ad\u548c\u9274\u522b\u8bca\u65ad\u4e2d\u6709\u91cd\u8981\u4ef7\u503c\u3002<\/p>\n \u603b\u4f53\u4e0a\u8bf4 BNP\/ NT-proBNP \u6307\u6807\u5728\u6025\u6027\u5fc3\u8870\u4e2d\u7684\u4e34\u5e8a\u4ef7\u503c\u8981\u5927\u4e8e\u6162\u6027\u5fc3\u8870\u7684\u4e34\u5e8a\u4ef7\u503c\uff1b\u5728\u6025\u6027\u5fc3\u8870\u4e2d\u6392\u9664\u622a\u70b9\u7684\u53ef\u9760\u7a0b\u5ea6\u8981\u5927\u4e8e\u8bca\u65ad\u622a\u70b9\u7684\u53ef\u9760\u7a0b\u5ea6\u3002\u5728\u6025\u6027\u5fc3\u8870\u4e2d BNP \/ NT-proBNP \u76ee\u524d\u91c7\u7528\u6392\u9664\u622a\u70b9\u548c\u8bca\u65ad\u622a\u70b9\u7684\u53cc\u622a\u70b9\u8bca\u65ad\u7b56\u7565\uff0c\u5176\u6392\u9664\u622a\u70b9\u6bd4\u8bca\u65ad\u622a\u70b9\u66f4\u4e3a\u53ef\u9760\u3002<\/p>\n BNP \u7684\u6392\u9664\u622a\u70b9\u4e3a\uff1c100 pg\/ml\u3002NT-proBNPP \u7684\u6392\u9664\u622a\u70b9\u4e3a\uff1c300 pg\/m\u3002\u5373\u5982\u679c BNP \/ NT-proBNP \u5c0f\u4e8e\u6392\u9664\u622a\u70b9\uff0c\u5176\u6025\u6027\u5fc3\u8870\u7684\u53ef\u80fd\u6027\u662f\u5f88\u5c0f\u7684\u3002<\/p>\n BNP \u7684\u8bca\u65ad\u622a\u70b9\u4e3a \u2265 300 pg\/ml\u3002NT-proBNP \u7684\u8bca\u65ad\u622a\u70b9\u4e3a \u2265 450 pg\/ml\uff08\uff1c50 \u5c81\uff09\uff0c\u2265 900 pg\/ml\uff0850\uff0d75 \u5c81\uff09\uff0c\u2265 1800 pg\/ml\uff0875 \u5c81\uff09\u3002<\/p>\n \u9700\u8981\u6ce8\u610f\u7684\u662f\u5728\u6025\u6027\u5fc3\u8870\u8bca\u65ad\u4e2d BNP \/NT-proBNP \u8bca\u65ad\u622a\u70b9\u5e94\u7ed3\u5408\u4e34\u5e8a\u8868\u73b0\u548c\u5176\u5b83\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u7efc\u5408\u5f81\u5224\u5b9a\u3002<\/p>\n BNP \/ NT-proBNP \u4e0e\u6162\u6027\u5fc3\u8870<\/p>\n BNP \/ NT-proBNP \u6307\u6807\u5728\u6162\u6027\u5fc3\u8870\u8bca\u65ad\u548c\u9884\u540e\u7684\u8bc4\u4f30\u6709\u4e00\u5b9a\u4ef7\u503c\u3002<\/p>\n \uff081\uff09BNP \/ NT-proBNP \u5728\u6162\u6027\u5fc3\u8870\u4e2d\u7684\u6392\u9664\u622a\u70b9<\/p>\n \u5728\u6162\u5fc3\u8870\u4e2d BNP \/ NT-proBNP \u540c\u6837\u91c7\u7528\u6392\u9664\u622a\u70b9\u548c\u8bca\u65ad\u622a\u70b9\u7684\u53cc\u622a\u70b9\u8bca\u65ad\u7b56\u7565\u3002BNP \u7684\u6392\u9664\u622a\u70b9\u4e3a\uff1c35 pg\/ml\u3002NT-proBNPP \u7684\u6392\u9664\u622a\u70b9\u4e3a\uff1c125 pg\/ml\u3002\u5373\u5982\u679c BNP \/ NT-proBNP \u5c0f\u4e8e\u6392\u9664\u622a\u70b9\uff0c\u5176\u6162\u6027\u5fc3\u8870\u7684\u53ef\u80fd\u6027\u5f88\u5c0f\u3002<\/p>\n \uff082\uff09BNP \/ NT-proBNP \u5728\u6162\u6027\u5fc3\u8870\u4e2d\u7684\u8bca\u65ad\u622a\u70b9<\/p>\n \u8ba9\u5927\u5bb6\u5931\u671b\u4e86\uff0c\u8bca\u65ad\u6162\u6027\u5fc3\u529b\u8870\u7aed\u7684 BNP \/ NT-proBNP \u622a\u70b9\u96be\u4ee5\u786e\u5b9a\u3002\u8fd9\u662f\u56e0\u4e3a\u6162\u6027\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u7684 BNP \/ NT-proBNP \u6c34\u5e73\u603b\u4f53\u4f4e\u4e8e\u6025\u6027\u5fc3\u529b\u8870\u7aed\uff0c\u9700\u8981\u505a\u51fa\u7684\u9274\u522b\u8bca\u65ad\u8f83\u591a\uff0c\u5305\u62ec\u5404\u79cd\u53ef\u4ee5\u4f34\u6709 BNP\/NT-proBNP \u4e0d\u540c\u7a0b\u5ea6\u589e\u9ad8\u7684\u975e\u5fc3\u529b\u8870\u7aed\u75be\u75c5\uff0c\u5982\u6162\u6027\u80ba\u90e8\u75be\u75c5\u3001\u80ba\u52a8\u8109\u9ad8\u538b\u3001\u9ad8\u8840\u538b\u3001\u5fc3\u623f\u98a4\u52a8\u7b49\u3002<\/p>\n \u4e34\u5e8a\u5e94\u7ed3\u5408\u75c5\u53f2\u3001\u4e34\u5e8a\u8868\u73b0\u548c\u5176\u4ed6\u68c0\u67e5\u624b\u6bb5\u7684\u7ed3\u679c\u8fdb\u884c\u5206\u6790\uff0c\u4ee5\u8fdb\u4e00\u6b65\u63d0\u9ad8\u8bca\u65ad\u7684\u51c6\u786e\u6027\u3002<\/p>\n \uff083\uff09BNP \/ NT-proBNP \u5bf9\u6162\u6027\u5fc3\u529b\u8870\u7aed\u9884\u540e\u8bc4\u4f30\u4f5c\u7528<\/p>\n BNP \/NT-proBNP \u662f\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u6b7b\u4ea1\u548c\u518d\u6b21\u5165\u9662\u7684\u72ec\u7acb\u5371\u9669\u56e0\u7d20\u3002\u60a3\u8005\u5165\u9662\u5373\u68c0\u6d4b BNP \/NT-proBNP \u6709\u52a9\u4e8e\u8fdc\u671f\u98ce\u9669\u7684\u8bc4\u4f30\u3002\u4efb\u4f55\u65f6\u95f4\u5355\u6b21\u6d4b\u5b9a\u7684 BNP \/NT-proBNP \u5747\u6709\u52a9\u4e8e\u5371\u9669\u5206\u5c42\u3002\u91cd\u590d\u6d4b\u5b9a\u4f1a\u63d0\u4f9b\u66f4\u591a\u7684\u9884\u540e\u4fe1\u606f\u3002BNP \/NT-proBNP \u7684\u9884\u540e\u5224\u65ad\u4ef7\u503c\u901a\u5e38\u4f18\u4e8e\u5176\u4ed6\u7684\u751f\u7269\u6807\u8bb0\u7269\uff0c\u5982\u5185\u76ae\u7d20\u3001\u80be\u4e0a\u817a\u9ad3\u8d28\u7d20\u3001\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u03b1\u3001\uff23\uff0d\u53cd\u5e94\u86cb\u767d\u7b49\u3002<\/p>\n \uff084\uff09BNP \/ NT-proBNP \u4e0e NYHA \u5fc3\u529f\u80fd\u5206\u7ea7<\/p>\n \u8fd9\u662f\u4e00\u4e2a\u6bd4\u8f83\u6fc0\u52a8\u4eba\u5fc3\u7684\u95ee\u9898\u3002\u6162\u6027\u5fc3\u529b\u8870\u7aed\u60a3\u8005 BNP \/ NT-proBNP \u6c34\u5e73\u589e\u9ad8\u7684\u7a0b\u5ea6\u4e0e NYHA \u5fc3\u529f\u80fd\u5206\u7ea7\u548c\u4e8c\u7ef4\u8d85\u58f0\u5de6\u5fc3\u5ba4\u5c04\u8840\u5206\u6570\uff08LVEF\uff09\u5b58\u5728\u76f8\u5173\u6027\uff1a\u5fc3\u529f\u80fd\u5206\u7ea7\u8d8a\u9ad8\u3001LVEF \u8d8a\u4f4e\uff0cBNP \/ NT-proBNP \u589e\u9ad8\u8d8a\u663e\u8457\u3002<\/p>\n \u4f46\u662f\u5f88\u591a\u8bd5\u56fe\u5c06 BNP \/ NT-proBNP \u503c\u4e0e NYHA \u5fc3\u529f\u80fd\u5206\u7ea7\u5177\u4f53\u7ea7\u522b\u53ca LVEF \u5177\u4f53\u6570\u503c\u76f8\u5bf9\u5e94\u7684\u7814\u7a76\u6700\u7ec8\u7ed3\u679c\u5747\u4e0d\u4e00\u81f4\uff0c\u751a\u81f3\u76f8\u4e92\u77db\u76fe\u3002<\/p>\n 2012 ESC \u5fc3\u8870\u6307\u5357\u8ba4\u4e3a 6 \u5206\u949f\u6b65\u884c\u8bd5\u9a8c\u3001\u8fd0\u52a8\u5e73\u677f\u8bd5\u9a8c\u3001NHYA \u5fc3\u529f\u80fd\u5206\u7ea7\u6240\u4ee3\u8868\u7684\u8fd0\u52a8\u80fd\u529b\uff0c\u5176\u6838\u5fc3\u662f\u5cf0\u503c\u6c27\u8017\u91cf\u548c EF\u3001BNP \u7b49\u4ee3\u8868\u9759\u606f\u8840\u6d41\u52a8\u529b\u5b66\u6d4b\u91cf\u6307\u6807\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u8f83\u5dee\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5236\u5b9a\u4e8e 1928 \u5e74 NHYA \u5fc3\u529f\u80fd\u5206\u7ea7\u867d\u7136\u5728\u4e34\u5e8a\u4e0a\u5e7f\u4e3a\u4f7f\u7528\uff0c\u4f46\u5176\u5224\u5b9a\u6807\u51c6\u53d7\u4e3b\u89c2\u56e0\u7d20\u5f71\u54cd\u660e\u663e\uff0c\u540c\u65f6 II \/ III \u7ea7\u754c\u5b9a\u6807\u51c6\u8f83\u4e3a\u6a21\u7cca\u4e5f\u8fdb\u4e00\u6b65\u9020\u6210\u5b83\u4e0e BNP \/NT-proBNP \u503c\u4e4b\u95f4\u5bf9\u5e94\u5173\u7cfb\u8f83\u5dee\u3002<\/p>\n \u6700\u540e BNP \/ NT-proBNP \u4e2d\uff0c\u5c24\u5176\u662f NT-proBNP \u53d7\u5f71\u54cd\u56e0\u7d20\u8f83\u591a\uff0c\u6240\u4ee5\u5728\u4e34\u5e8a\u4e0a\u5f88\u96be\u5236\u5b9a\u5176\u4e0e NHYA \u5fc3\u529f\u80fd\u5206\u7ea7\u76f8\u5bf9\u5e94\u7684\u6570\u503c\u8303\u56f4\u3002<\/p>\n \u6700\u540e\u7ed9\u4eb2\u4eec\u4e0a\u4e2a BNP \/ NT-proBNP \u5728\u6025\u6162\u6027\u5fc3\u8870\u4e2d\u7684\u8bca\u65ad\u6d41\u7a0b\u56fe\uff0c\u773c\u5c16\u7684\u670b\u53cb\u53ef\u4ee5\u770b\u5230\u5982\u679c\u987a\u7740\u7070\u8272\u8bca\u65ad\u8def\u5f84\u53ef\u4ee5\u7701\u53bb 2 \u5904\u8d85\u58f0\u5fc3\u52a8\u56fe\u7684\u8d39\u7528\u3002<\/p>\n BNP \/ NT-proBNP \u4e0e\u8212\u5f20\u6027\u5fc3\u529b\u8870\u7aed<\/p>\n \u8212\u5f20\u6027\u5fc3\u529b\u8870\u7aed\u662f\u6307\u4e00\u7ec4\u5177\u6709\u5fc3\u529b\u8870\u7aed\u7684\u75c7\u72b6\u6216\u4f53\u5f81\u3001\u5de6\u5fc3\u5ba4\u5c04\u8840\u5206\u6570\u6b63\u5e38\u800c\u4ee5\u5fc3\u5ba4\u8212\u5f20\u529f\u80fd\u969c\u788d\u3001\u987a\u5e94\u6027\u51cf\u9000\u3001\u50f5\u786c\u5ea6\u589e\u9ad8\u4e3a\u7279\u70b9\u7684\u4e34\u5e8a\u7efc\u5408\u5f81\u3002<\/p>\n \u8d85\u58f0\u5fc3\u52a8\u56fe\u68c0\u67e5\u662f\u8212\u5f20\u6027\u5fc3\u529b\u8870\u7aed\u91cd\u8981\u7684\u8bca\u65ad\u4f9d\u636e\uff0c\u800c\u8fd1\u5e74 BNP \/NT-proBNP \u68c0\u67e5\u5df2\u7ecf\u6210\u4e3a\u8212\u5f20\u6027\u5fc3\u529b\u8870\u7aed\u91cd\u8981\u7684\u8f85\u52a9\u8bca\u65ad\u4f9d\u636e\u3002<\/p>\n \u5982\u679c\u60a3\u8005\u6709\u5fc3\u529b\u8870\u7aed\u7684\u75c7\u72b6\u6216\u4f53\u5f81\uff0c\u540c\u65f6 EF \ufe65 50% \u4e14\u5de6\u5ba4\u8212\u5f20\u672b\u5bb9\u79ef\u6307\u6570\uff1c97 bnp=””\uff1e200 pg\/ml \u6216 NT-proBNP \uff1e220 pg\/ml \u5e76\u5408\u5e76\u6709 E\/E\u300f\uff1e8 \u3001E\/A \uff1c1\u3001\u5de6\u623f\u6269\u5927\u3001\u5de6\u5ba4\u80a5\u539a\u3001\u80ba\u9759\u8109\u8840\u6d41\u9891\u8c31 S\/D \u589e\u9ad8\u3001\u623f\u98a4\u4e2d\u7684\u4efb\u610f\u4e00\u9879\uff0c\u53ef\u8003\u8651\u8212\u5f20\u6027\u5fc3\u529b\u8870\u7aed\u3002<\/p>\n \u4e0b\u56fe A \u548c B \u8def\u5f84\uff0c\u8d85\u58f0\u8bca\u65ad\u8212\u5f20\u6027\u5fc3\u529b\u8870\u7aed\u4f9d\u636e\u5145\u8db3\u3002C \u8def\u5f84\u56e0\u4ec5\u6709 6 \u4e2a\u5e76\u5217\u6307\u6807\u4e4b\u4e00\uff0c\u6545\u4f9d\u636e\u4e0d\u5145\u8db3\uff0c\u5982 C \u4efb\u4e00\u6307\u6807\u52a0 BNP >200 pg\/ml \u6216 NT-proBNP > 220 pg\/ml \u4e5f\u53ef\u8bca\u65ad\u8212\u5f20\u6027\u5fc3\u529b\u8870\u7aed\u3002<\/p>\n BNP \/NT-proBNP \u4e0e\u51a0\u5fc3\u75c5<\/p>\n \u51a0\u5fc3\u75c5\u5fc3\u808c\u7f3a\u8840\u53ef\u5f15\u8d77 BNP \/ NT-proBNP \u7684\u5347\u9ad8\uff0c\u4e3b\u8981\u7684\u673a\u5236\u6709\u5fc3\u808c\u7f3a\u8840\u7f3a\u8840\u4f7f\u5fc3\u5ba4\u8212\u7f29\u529f\u80fd\u969c\u788d\u5f15\u8d77\u5fc3\u808c\u7275\u62c9\uff0c\u800c\u5fc3\u808c\u7f3a\u8840\u7f3a\u6c27\u672c\u8eab\u4e5f\u80fd\u523a\u6fc0 BNP \/NT-proBNP \u7684\u4ea7\u751f\u3002<\/p>\n \u5176\u4ed6\u56e0\u7d20\u8fd8\u5305\u62ec\u5fc3\u7387\u589e\u5feb\u3001\u8840\u7ba1\u6536\u7f29\u3001\u6297\u5229\u5c3f\u4f5c\u7528\u3001\u5fc3\u808c\u80a5\u539a\u548c\u7ec6\u80de\u589e\u751f\u7b49\u3002\u56e0\u6b64\u5728\u6025\u6027\u51a0\u8109\u7efc\u5408\u5f81\uff08ACS\uff09\u548c\u6162\u6027\u7a33\u5b9a\u6027\u51a0\u5fc3\u75c5\u4e2d\u90fd\u4f1a\u4e0d\u540c\u7a0b\u5ea6\u5f15\u8d77 BNP\/NT-proBNP \u7684\u5347\u9ad8\u3002<\/p>\n \u5bf9\u4e8e ACS \u5176\u4e3b\u8981\u4e34\u5e8a\u610f\u4e49\u5728\u4e8e\u534f\u52a9 ACS \u5f15\u8d77\u5fc3\u8870\u7684\u8bca\u65ad\uff0c\u800c\u5bf9\u4e8e\u6162\u6027\u7a33\u5b9a\u6027\u51a0\u5fc3\u75c5\u5176\u4e3b\u8981\u4e34\u5e8a\u610f\u4e49\u5728\u4e8e\u9884\u6d4b\u8fdc\u671f\u6b7b\u4ea1\u98ce\u9669\u3002<\/p>\n \u80be\u529f\u80fd\u4e0d\u5168<\/p>\n \u8fd9\u4e2a\u91cd\u8981\u95ee\u9898\u5728\u76f8\u5173\u7684\u4e13\u5bb6\u5171\u8bc6\u4e2d\u5e76\u672a\u63d0\u53ca\u3002\u866b\u54e5\u8eab\u8fb9\u5c31\u66fe\u53d1\u751f\u8fc7\u4e00\u4e2a\u9ebb\u9189\u79d1\u4e3b\u4efb\u56e0\u4e3a\u5bf9 NT-proBNP \u8ba4\u8bc6\u4e0d\u8db3\uff0c\u786c\u662f\u628a\u4e00\u4e2a\u6162\u80be NT-proBNP 5800 pg\/ml \u7684\u60a3\u8005\u786c\u662f\u4ece\u624b\u672f\u53f0\u4e0a\u8d76\u4e0b\u6765\uff0c\u81f3\u4eca\u8fd8\u6ca1\u505a\u624b\u672f\u3002<\/p>\n \u4f17\u591a\u7684\u7814\u7a76\u5747\u8868\u660e\u5728 BNP \/ NT-proBNP \u4e2d\uff0c\u80be\u529f\u80fd\u4e0d\u5168\u5bf9 NT-proBNP \u7684\u5f71\u54cd\u8981\u5927\u4e8e BNP\uff0c\u8fd9\u662f\u7531\u4e8e NT-proBNP \u4e3b\u8981\u5728\u80be\u810f\u6e05\u9664\uff0c\u800c BNP \u4e3b\u8981\u5728\u5916\u5468\u5faa\u73af\u6e05\u9664\u3002<\/p>\n \u6240\u4ee5\u6211\u4eec\u5728\u5e94\u7528 BNP \/ NT-proBNP \u6307\u6807\u5c24\u5176\u662f NT-proBNP \u65f6\uff0c\u4ecd\u8981\u6ce8\u610f\u4ee5\u4e0b\u51e0\u4e2a\u65b9\u9762\u7684\u95ee\u9898\u3002<\/p>\n 1. \u5c3d\u7ba1 NT-proBNP \u8bbe\u5b9a\u5e74\u9f84\u5206\u5c42\u622a\u70b9\u6821\u6b63\u4e86\u968f\u5e74\u9f84\u589e\u957f\u800c\u80be\u529f\u80fd\u4e0b\u964d\u7684\u95ee\u9898\uff0c\u4f46\u5e76\u6ca1\u6709\u8003\u8651\u5230\u5176\u5b83\u75c5\u56e0\u5982\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u538b\u75c5\u5bf9\u80be\u529f\u80fd\u7684\u5f71\u54cd\u3002\u867d\u7136\u8fd9\u4e9b\u60a3\u8005\u4e0d\u4e00\u5b9a\u90fd\u4f1a\u53d1\u5c55\u5230\u7cd6\u5c3f\u75c5\u80be\u75c5\u3001\u9ad8\u8840\u538b\u80be\u635f\u5bb3\u7684\u9636\u6bb5\uff0c\u4f46\u8fd9\u4e9b\u75be\u75c5\u5bf9\u80be\u529f\u80fd\u7684\u5f71\u54cd\u662f\u72ec\u7acb\u4e8e\u5e74\u9f84\u56e0\u7d20\u4e4b\u5916\u7684\u4e14\u4e0d\u53ef\u5ffd\u7565\u3002<\/p>\n 2. \u5728\u6162\u6027\u80be\u529f\u80fd\u4e0d\u5168\u4e2d\uff0c\u57fa\u4e8e GFR \u6307\u6807\u4e0e NT-proBNP \u503c\u4e4b\u95f4\u7684\u7814\u7a76\u672a\u80fd\u5f97\u51fa\u4e00\u4e2a\u53ef\u4e3a\u4e34\u5e8a\u91c7\u7eb3\u7684\u6821\u6b63\u516c\u5f0f\u6216\u622a\u70b9\uff0c\u8fd9\u4f7f\u5f97\u5728\u6162\u6027\u80be\u529f\u80fd\u4e0d\u5168\u60a3\u8005\u4e2d NT-proBNP \u6307\u6807\u89e3\u8bfb\u8f83\u4e3a\u56f0\u96be\uff0c\u4e34\u5e8a\u4ef7\u503c\u4e5f\u6253\u4e86\u6298\u6263\u3002<\/p>\n 3. \u5728\u4e34\u5e8a\u4e2d\u5fc3\u8870\u4e0e\u80be\u8870\u901a\u5e38\u540c\u65f6\u5b58\u5728\uff0c\u4e92\u4e3a\u56e0\u679c\u3002\u5fc3\u80be\u7efc\u5408\u5f81\u5206 5 \u578b\uff1a<\/p>\n I \u578b \u6025\u6027\u5fc3\u529f\u80fd\u635f\u4f24\u5f15\u8d77\u6025\u6027\u80be\u529f\u80fd\u635f\u4f24\uff1b<\/p>\n II \u578b \u6162\u6027\u5fc3\u529f\u80fd\u635f\u4f24\u5f15\u8d77\u6162\u6027\u80be\u529f\u80fd\u635f\u4f24\uff1b<\/p>\n III \u578b \u6025\u6027\u80be\u529f\u80fd\u635f\u4f24\u5f15\u8d77\u6025\u6027\u5fc3\u529f\u80fd\u635f\u4f24\uff1b<\/p>\n IV \u578b \u6162\u6027\u80be\u529f\u80fd\u635f\u4f24\u5f15\u8d77\u6162\u6027\u5fc3\u529f\u80fd\u635f\u4f24\uff1b<\/p>\n V \u578b\u6025\u6027\u6216\u6162\u6027\u5168\u8eab\u6027\u75be\u75c5\u6240\u81f4\u7684\u5fc3\u80be\u529f\u80fd\u4e0d\u5168\u3002<\/p>\n \u65e2\u7136\u65e0\u8bba\u5728\u6025\u6162\u6027\u5fc3\u8870\u4e2d\uff0c\u80be\u8870\u7684\u51fa\u73b0\u603b\u662f\u5982\u5f71\u968f\u5f62\uff0c\u90a3\u4e48\u4f7f\u7528\u53d7\u80be\u529f\u80fd\u5f71\u54cd\u5982\u6b64\u663e\u8457\u7684\u6307\u6807\u8bc4\u5b9a\u5fc3\u8870\uff0c\u4e0d\u80fd\u4e0d\u8bf4\u662f\u4e2a\u786c\u4f24\u3002<\/p>\n \u597d\u4e66\u63a8\u8350\uff1a<\/p>\n \u300a\u5fc3\u8840\u7ba1\u5185\u79d1\u533b\u5e08\u6210\u957f\u624b\u518c\u300b\u7531\u4e01\u9999\u56ed\u5fc3\u8840\u7ba1\u8bba\u575b\u4e00\u767e\u591a\u4f4d\u6765\u81ea\u4e8e\u5168\u56fd\u5404\u5730\u70ed\u7231\u5fc3\u8840\u7ba1\u4e13\u4e1a\u7684\u5e74\u8f7b\u533b\u751f\uff0c\u5386\u7ecf\u4e09\u5e74\u591a\u7684\u915d\u917f\u548c\u4e66\u5199\uff0c\u5171\u540c\u521b\u4f5c\u5b8c\u6210\u3002 \u4e66\u7c4d\u6db5\u76d6\u5fc3\u8840\u7ba1\u57fa\u7840\u77e5\u8bc6\u3001\u5fc3\u7535\u56fe\u3001\u8d85\u58f0\u3001\u5f71\u50cf\u3001\u8840\u6e05\u5b66\u6307\u6807\u89e3\u8bfb\u3001\u4e34\u5e8a\u6848\u4f8b\u5206\u6790\u3001\u5e38\u7528\u836f\u7269\u4f7f\u7528\u65b9\u6cd5\u7b49\uff0c\u5185\u5bb9\u7fd4\u5b9e\u7ec6\u81f4\u3002\u4e3b\u8981\u9762\u5411\u5373\u5c06\u8d70\u4e0a\u5de5\u4f5c\u5c97\u4f4d\u7684\u533b\u5b66\u751f\u548c\u521a\u521a\u8e0f\u5165\u5de5\u4f5c\u5c97\u4f4d\u7684\u89c4\u966a\u533b\u751f\uff0c\u6b22\u8fce\u5165\u624b\u9605\u8bfb\u3002<\/p>\n http:\/\/heart.dxy.cn\/article\/141398<\/p>\n","protected":false},"excerpt":{"rendered":" \uff08\u661f\u661f\u751f\u6d3b\u8bb0\u8005\u6377\u514b\u4f73\u7f16\u8bd1\u62a5\u9053\uff09\u5728\u533b\u9662\u548c\u5bb6\u4e2d\u8fdb\u884c\u5fc3\u529b\u8870\u7aed\u76d1\u6d4b\u5c06\u4f1a\u53d8\u5f97\u66f4\u52a0\u7b80\u5355\u6709\u6548\u53ca\u4fbf\u5b9c\uff0c\u8fd9\u5f97\u76ca\u4e8e\u6ed1\u94c1\u5362\u5927\u5b66Mitacs\u7814\u7a76\u4eba\u5458\u4ee5\u53ca\u5bc6\u897f\u6c99\u52a0\u521d\u521b\u516c\u53f8LeNano Diagnostics\u5408\u4f5c\u5f00\u53d1\u5e76\u9996\u521b\u7684\u6307\u523a\u6d4b\u8bd5\u6280\u672f\u3002 \u4f5c\u4e3a\u4e00\u9879\u98a0\u8986\u6027\u6280\u672f\uff0c\u8be5\u5957\u4eea\u5668\u7c7b\u4f3c\u4e8e\u4e3a\u7cd6\u5c3f\u75c5\u60a3\u8005\u8fdb\u884c\u6d4b\u8bd5\u7684\u8840\u7cd6\u4eea\u3002\u60a3\u8005\u53ea\u9700\u523a\u7834\u624b\u6307\uff0c\u5c06\u8840\u6db2…
\n\u8bf4\u4f60\u957f\u7684\u9ad8\uff0c\u597d\uff01\u4f60\u6709\u5e0c\u671b\u8c61\u59da\u660e\uff0c\u53f1\u54a4\u7bee\u575b\uff1b\u8bf4\u4f60\u957f\u7684\u77ee\uff0c\u597d\uff01\u4f60\u6709\u5e0c\u671b\u8c61\u6768\u5229\u4f1f\uff0c\u4e5d\u5929\u63fd\u6708\u3002\u603b\u4e4b\uff0c\u5144\u5f1f\u4f60\u524d\u9014\u65e0\u91cf\u3002
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Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":51743,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=\/wp\/v2\/posts\/51736"}],"collection":[{"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=51736"}],"version-history":[{"count":4,"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=\/wp\/v2\/posts\/51736\/revisions"}],"predecessor-version":[{"id":51744,"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=\/wp\/v2\/posts\/51736\/revisions\/51744"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=\/wp\/v2\/media\/51743"}],"wp:attachment":[{"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=51736"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=51736"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.jackjia.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=51736"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}